This document provides an ESCMID Emerging Infections Subcommittee situation update on the 2026 Ebola Bundibugyo outbreak in the Democratic Republic of the Congo and Uganda. Its purpose is to inform healthcare professionals, microbiologists, public health authorities, and ESCMID members about the current epidemiological situation, major clinical and public health challenges, regional and international risks, and recommended preparedness measures. The document also highlights the importance of surveillance, infection prevention, healthcare worker protection, laboratory readiness, and international coordination while emphasising the urgent need for research and development of vaccines, diagnostics, and therapeutics for non-Zaire ebolaviruses.
