This course extensively explores the pathogenesis of intracellular bacteria, covering infiltration, immune evasion, and replication mechanisms. It addresses host-pathogen interactions, clinical presentations, One-Health aspects, and diagnostic methods such as molecular assays, serology, culture, and microscopy. Treatment strategies, challenges of drug resistance, and persistence in intracellular pathogens are discussed, supplemented by case studies and current research for real-world insights. Networking opportunities for potential European collaborations in clinical or basic research are integrated. Furthermore, current outbreaks (Mycoplasma pneumoniae and Chlamydia pneumoniae) will be discussed during the course.
Intended audience:
Clinical microbiologists and infectious disease specialists interested in diagnosing and treating intracellular bacteria, namely Chlamydia spp., Legionella, Mycobac-teria, Coxiella, Rickettsia, Bartonella and Listeria, as well as bacteria of fastidious growth such as Mycoplasma. As molecular diagnosis is often required for such pathogens, may be interesting for infectious diseases specialists involved more broadly in this field as well as actors involved in One-Health aspects of intracellular bacteria (epidemiologists and veterinaries). This course is suitable for early career and advanced clinicians (microbiologists or infectious diseases specialists) or scientists and combines plenary sessions, clinical cases presentations and panel discussions.
Objectives:
In this course, participants will explore the pathogenesis of clinically important intracellular bacteria. They will learn how they infiltrate host cells, evade the immune system, and replicate within their hosts. The course will also delve into host-pathogen interactions, analysing the various molecular mechanisms developed by the bacteria to interact with the host and modify its responses. The clinical presentation of diseases caused by intracellular bacteria will be examined, enabling participants to recognize the distinct symptoms and exposure associated with such infections. In addition, particular One-Health aspects of intracellular bacteria will be discussed during this course. Participants will be introduced to various diagnostic methods (molecular assays, serology, culture, microscopy) with an emphasis on the importance of timely and accurate diagnosis in managing intracellular bacterial infections. Treatment strategies targeting these organisms will be discussed. There will be a focus on the challenges posed by drug resistance and persistence in these pathogens. The course will feature case studies and provide insight into current research in the field, to put the knowledge into real clinical experiences. Lastly, this course aims to create a networking environment between members of the field, to enable potential European collaboration for clinical or basic research as well as to offer the opportunities for early career participants to meet experts in the field (and thus promote their careers).
Course coordinator:
Gilbert Greub, Lausanne, Switzerland
Florian Tagini, Lausanne, Switzerland
Organisers:
ESGMAC, ESGMD, ESGMYC, ESGVM, ESCCAR
Accreditation:
ESCMID Office will apply for accreditation.
Certification:
Course organisers will monitor attendance. Only participants attending live sessions will be able to receive the certification.
Course Venue:
Lausanne University Hospital (CHUV), zones des auditoires
(Auditoire Chalotte-Olivier), Lausanne, Switzerland
Rue du Bugnon 46, 1011 Lausanne, Switzerland
www.chuv.ch/fr/chuv-home
Accommodation:
Aquatis Hôtel
Route de Berne 148 1010 Lausanne Vaud - Suisse
Website: www.aquatis-hotel.ch
Phone:+41 21 654 24 24
E-Mail: info(at)aquatis-hotel.ch
Hôtel des patients
Avenue de la Sallaz 8,1005 Lausanne
Website: www.hoteldespatients.ch
Phone: +41 21 545 41 11
E-Mail: reception.lausanne(at)hoteldespatients.ch
Registration details:
The registration fee includes tuition, meals, coffee breaks, and social activities (dinner, entrance to the museum exhibition “World of Microbes”). Travel and accommodation costs are not included.
Attendance Grant application
Attendance grant application is closed.