Carbapenemases in Enterobacteriaceae: Challenges and Preparedness, ESCMID Postgraduate Education Course

24 - 25 September 2015, Verona, Italy

  • ESCMID Study Group for Antimicrobial Resistance Surveillance (ESGARS)
  • European Committee on Infection Control (EUCIC)
  • Italian Society for Microbiology

Course Coordinator

Giuseppe Cornaglia, Verona, Italy

Course Objectives

The prevalence of multidrug-resistant Enterobacteriaceae that produce carbapenemases (CRE) is steadily increasing worldwide, approaching or even attaining the endemicity threshold in many countries. Rapid and reliable
CRE detection is crucial for effective patient management, as well as for infection prevention and for control and surveillance purposes. The proposed course will debate how to effectively detect carbapenemases in routine testing, and how to report their presence to clincians. These goals will be pursued by providing the participants with the basic, integrated elements necessary for understanding the nature of carbapenemases, as well as the need for correct identification and reporting. Lectures will be followed by practical demonstrations of the main diagnostic techniques. Guidelines for appropriate infection control and basic options for clinical treatment are also part of the main scope of this course.

Course Venue

Aula Roberto Vecchioni
Policlinico “G.B. Rossi”
Piazzale L.A. Scuro
37134 Verona

Full course (including afternoon practicals):
25 – 35 clinical microbiologists and infectious disease specialists.

Mini course (morning lectures only, not including afternoon practicals):

65 – 75 clinical microbiologists and infectious disease specialists, or other clinicians with documented interest in the infection problem.

Contact Person

Giuseppe Cornaglia
University of Verona
Department of Pathology and Diagnostics
Strada Le Grazie, 8
37134 Verona, Italy

Phone +39 335 825 81 66
Fax +39 335 802 71 11

Administrative Secretariat

Marco Moschin
Via Lorenzo Marcello, 32
30126 Lido Di Venezia, Italy

Phone +39 041 526 25 30
Fax +39 041 887 22 91

Course Programme
Presentations are availabe in the ESCMID Online Lecture Library.

Thursday, 24 September 2015

09:00 The non-contained outbreak: worldwide diffusion of                                                      CR-Enterobacteriaceae in 2015. Giuseppe Cornaglia
09:30 Spectrum of activity and in-vitro susceptibility patterns.
           Marek Gniadkowski
10:00 Interplay between carbapenemase expression and other resistance
           mechanisms. Luis Martinez Martinez
10:30 Coffee break
11:00 Multiple genetic vectors as a source of spread of carbapenemase                           producers. Laurent Poirel
11:30 When and how to suspect the presence of carbapenemases                                    (novel and well known enzymes)? Patrice Nordmann
12:00 Detection of carbapenemases with MALDI-TOF. Jaroslav Hrabak
12:30 The role and contribution of reference labs in Europe. Marek Gniadkowski
13:00 Reporting to clinicians: the breakpoint issue. Christian Giske
13:30 Lunch
14:30 Practicals:

  • Chromogenic media
  • Phenotypic tests
  • CarbaNP test

Friday, 25 September 2015

09:00 Risk factors for carbapenemases inside and outside the hospital.
           Jesús Rodríguez Baño
09:30 Guidelines to reduce transmission of MDR Enterobacteriaceae.
           Evelina Tacconelli
10:00 Screening carriers and at-risk patients. Annarita Mazzariol
10:30 Coffee break
11:00 Isolation and containment. Evelina Tacconelli
11:30 May carbapenems be used in therapy? George Daikos
12:00 Therapeutic alternatives to carbapenems. Jesús Rodríguez Baño
12:30 Future and perspectives. Patrice Nordmann
13:00 Lunch
14:00 Practicals

  • Classical hydrolysis tests
  • Hydrolysis test with MALDI-TOF
  • Molecular tests
Faculty Members
  • Giuseppe Cornaglia, Verona, Italy
  • George Daikos, Athens, Greece
  • Christian Giske, Stockholm, Sweden
  • Marek Gniadkowski, Warsaw, Poland
  • Jaroslav Hrabak, Plzen, Czech Republic
  • Luis Martinez Martinez, Santander, Spain
  • Annarita Mazzariol, Verona, Italy
  • Patrice Nordmann, Fribourg, Switzerland
  • Laurent Poirel, Fribourg, Switzerland
  • Jesús Rodríguez Baño, Seville, Spain
  • Evelina Tacconelli, Tübingen, Germany

CME Accreditation

The course was accredited with 12 CME points through EACCME.