Virulence and Resistance in Staphylococcus aureus: 2016 State of the Art, ESCMID Postgraduate Education Course

28 June - 1 July 2016, Lyon, France


ESCMID Study Group for Staphylococci and Staphylococcal Diseases (ESGS)

  • The European Committee on Antimicrobial Susceptibility Testing (EUCAST)
  • ESCMID Study Group for Antimicrobial Resistance Surveillance (ESGARS)
  • ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS)
  • ESCMID Study Group for Epidemiological Markers (ESGEM)
  • ESCMID PK/PD of Anti-Infectives Study Group (EPASG)
Course Coordinators
  • Frédéric Laurent, Lyon, France
  • François Vandenesch, Bron, France
Course Objectives
  • To provide to postgraduate microbiologists and infectious disease physicians (with basic knowledge in bacteriology) an updated overview of pathophysiology and resistance in Staphylococcus
  • To give to participants the opportunity to have state of the art, new insights and scientific exchanges on virulence and resistance on these pathogens including:
    – Mechanisms of resistance and virulence in vivo data, clinical management
    – Screening, detection and identification of virulence and resistance determinants in the daily lab
    – Infection control practice
Course Venue

Lyon-East Medical School
Institute of Pharmaceutical and
Biological Sciences
University of Lyon
8 avenue Rockefeller
69008 Lyon, France

Target Audience

20 – 40 young microbiologists and infectious disease physicians with basic knowledge in bacteriology.

Contact Person (Scientific Programme)

Frédéric Laurent
Institut de Microbiologie
Laboratoire de Bactériologie
Centre National de
Reference des staphylocoques
59 Boulevard Pinel
Bron Cedex, France

Phone +33 472 071 837
Fax +33 472 129 626

Administrative Secretariat

Hélène Meugnier
Institut de Microbiologie
Laboratoire de Bactériologie
Centre National de
Reference des staphylocoques
59 Boulevard Pinel
Bron Cedex, France

Phone +33 472 129 621
Fax +33 472 129 626

Course Programme

Presentations are availabe in the ESCMID Online Lecture Library.


Tuesday, 28 June 2016

13:30 Staphylococcal cell wall-associated virulence factors. Mathias Herrmann
15:00 Mechanisms of action of staphylococcal toxins (PVL and pore-forming toxins, exfoliatins, PSMs, superantigens). Gerard Lina & Oliver Dauwalder
16:15 Intracellular lifestyle of S. aureus. To be confirmed
17:15 Regulation of virulence in S. aureus: non-coding RNA, virulence and global regulators.
Thomas Geissmann & Tarek Msadek

Wednesday, 29 June 2016

08:00 Staphylococcus: from commensalism/ colonization to infection and decolonization. Stephan Harbarth
08:45 Pathophysiology of staphylococcal bone and joint infection.
Frédéric Laurent & Tristan Ferry

10:45 Pathophysiology of staphylococcal bacteraemia and endocarditis.
Coralie Bouchiat & Winfried Kern

13:30 Pathophysiology of staphylococcal skin and soft tissue infections.
Anne Tristan & Yves Gillet

14:30 Biofilm-associated catheter infections and Staphylococcus.
David Lebeaux & Florent Valour

15:45 Staphylococcus aureus and cystic fibrosis. Barbara Kahl
16:15 Staphylococcal colonization and infection in animals: epidemiology, pathophysiology and management. Luca Guardabassi
17:15 Staphylococcal virulence through WGS. François Vandenesch

Thursday, 30 June 2016

08:30 Antimicrobial susceptibility tests for Staphylococcus and EUCAST recommendations. Rafael Canton
09:15 Anti-staphylococcal activity of antibiotics in biofilm and host cells.
Françoise Van Bambeke

10:30 Beta-lactams. Frédéric Laurent & Robert Skov

  • Mechanisms of action: from SASM to SARM
  • Genetic support of beta-lactam resistance: bla, mec gene alphabet and PLP alteration
  • Screening, detection, determination of beta-lactam resistance in routine

14:00 Lipo- and glyco-peptides. Oana Dumitrescu

  • Mechanisms of action
  • Phenotypic and genetic support of resistance: from VSSA to h-VISA, VISA and VRSA... from van to multi-faceted mutations
  • Detection of resistance in my lab: why, when and how?
  • In vivo activity and clinical case

16:00 Oxazolidones. Angela Kearns & Céline Dupieux

  • Mechanisms of action
  • Mutational and plasmidic resistances
  • Detection of resistance in routine
  • In vivo activity and clinical use

16:45 Animals and resistance in S. aureus. Stefan Schwarz
17:20 Epidemiology and prevalence of antibiotic resistance. Arjana Tambic

Friday, 1 July 2016

08:15 Anti-staphylococcal antibiotics: the new ones and the future ones. Florent Valour
08:45 New approaches to circumvent Staphylococcus multi-resistance. Johan Mouton
09:15 WGS and resistance in Staphylococcus: from research to routine. Jodi Lindsay
10:30 Population genetics in S. aureus. Thierry Wirth
11:10 Epidemiology and dynamics of virulence resistant S. aureus clones. Hajo Grundmann
11:50 Resistance and virulence in S. aureus: an intergrative approach.
Jean-Phillipe Rasigade

Faculty Members
  • Coralie Bouchiat, Lyon, France
  • Rafael Canton, Madrid, Spain
  • Olivier Dauwalder, Bron, France
  • Oana Dumitrescu, Lyon, France
  • Céline Dupieux, Lyon, France
  • Tristan Ferry, Lyon, France
  • Thomas Geissmann, Lyon, France
  • Yves Gillet, Lyon, France
  • Hajo Grundmann, Freiburg, Germany
  • Luca Guardabassi, Basseterre, Saint Kitts and Nevis
  • Stephan Harbarth, Geneva, Switzerland
  • Mathias Herrmann, Homburg/Saar, Germany
  • Barbara Kahl, Münster, Germany
  • Angela Kearns, London, United Kingdom
  • Winfried Kern, Freiburg, Germany
  • Frédéric Laurent, Lyon, France
  • David Lebeaux, Paris, France
  • Gerard Lina, Lyon, France
  • Jodi Lindsay, London, United Kingdom
  • Johan Mouton, Rotterdam, Netherlands
  • Tarek Msadek, Paris, France
  • Jean-Philippe Rasigade, Lyon, France
  • Stefan Schwarz, Neustadt-Mariensee, Germany
  • Robert Skov, Copenhagen, Denmark
  • Arjana Tambic, Zagreb, Croatia
  • Anne Tristan, Lyon, France
  • Florent Valour, Lyon, France
  • Françoise Van Bambeke, Brussels, Belgium
  • François Vandenesch, Bron, France
  • Thierry Wirth, Paris, France

CME Accreditation

The organizers of the course will apply for European CME accreditation through EACCME.