2009 recipient of ISF-ESCMID Sepsis Award

Caroline Landelle
born 1978 in Chambery, France; PharmD, PhD student at the Laboratoire d’Epidémiologie et Santé Publique, Université Claude Bernard, Lyon, France, in recognition of her excellent abstract submitted for presentation at the 19th ECCMID.

Research Interests
Caroline Landelle’s main interest is the epidemiology of nosocomial infections (NI) and their prevention with a focus on the risk factors of NI in critically ill patients. During her doctoral work, she studied the association between immunosuppression and incidence of NI after septic shock. A low monocyte human leucocyte antigen-DR (mHLA-DR), which is a marker of immunosuppression, was independently associated with occurrence of NI after septic shock, after adjustment to clinical parameters. This promising biomarker may be of major interest in defining patients at increased risk of NI who could benefit from immunostimulatory treatments. This thesis work was performed at the University Claude Bernard and at the Hospices Civils de Lyon, Lyon, France under the supervision of P. Vanhems, and in collaboration with immunologists (G. Monneret), intensivists (A. Lepape) and hospital-based infection-control practitioners.