Principles of antimicrobial stewardship: the what and the how

13 - 17 June 2022

Nijmegen, the Netherlands



Dutch Working Party on Antibiotic Policy (Dutch acronym is SWAB)

Module objectives

This module is intended as the basic course AMS for the new ESCMID AMS European certificate, covering in-depth the principles and practices of AMS. Participants will be prepared for research and academic positions, teaching roles in national and international AMS organisations, professions in Antimicrobial Stewardship Programmes for healthcare institutions, and government positions.

Target Audience

ID Physicians, Medical Microbiologists, Clinical Pharmac(olog)ists, ICU physicians, Internists, Specialist Nurses, Pediatricians and other medical specialties.

Module venue

Fletcher Hotel Erica

Molenbosweg 17

6571 BA Berg en Dal

The Netherlands

Preliminary programme


Day 1


Antimicrobial Stewardship Introduction / General principles of antimicrobial therapy


09:00 – 09:15

Welcome and introduction

Dr. Jeroen Schouten

09:15 – 10:00

BASIC requirements of an Antimicrobial stewardship Program, an interactive overview

Dr. Jaap ten Oever     

10:00 – 10:30

BASIC requirements of an Antimicrobial stewardship Program, the role of Microbiology (diagnostic stewardship)

Prof. dr. Heiman Wertheim

10:30 – 11:00

The WHAT of antimicrobial stewardship (objectives)

Prof. dr. Jan Prins


11:15 – 11:45

Epidemiology of resistance. Current situation and trends in Europe. How do you weigh this? Where do you get the (local) data from? How does this affect outcomes?

Dr. Mark de Boer

11:45 – 12:30

Interdisciplinary consultations: a lesson in empathy / combining multiple perspectives

Prof. Dr. Bhanu Sinha

AFTERNOON Workshop Implementation in practice (part I) “What is exactly my problem?”

13:30 – 14:30

The HOW of antimicrobial stewardship: how do I make sure that what is implemented/performed in daily practice

Prof. Dr. Marlies Hulscher

14:30 – 15:00

Presentation of a “My project” performed by a course Alumnus: “How did I approach my own Antimicrobial Stewardship problem and improve ? “


15:00 – 16:30

Workshop: introduction of all participants to their main AMS problem: group discussion to define one major problem per group.


16:30 – 18:00

Social Event (Bike tour / Walk in the woods)




Optimizing Antimicrobial therapy

09:00 – 09:45

Practical PK/PD: Leads for optimal dosing, also in situations of altered organ function

Dr. Nynke Jager

09:45 – 10:30

EUCAST methodology of breakpoints , clinical breakpoints, ECOFFs and susceptibility Dr. Anouk Muller


11:00 – 11:45

Practical PK/PD: therapeutic drug monitoring (TDM) to optimize efficacy and prevent toxicity

Dr. Reinier van Hest

11:45 – 12:30

How to manage (suspected) antibiotic allergy and possibilities for stewardship

Dr. Mark de Boer

AFTERNOON Workshop Implementation in practice (part IIa) “How do I measure the quantity of antimicrobial use?”


13:30 – 14:00

Quantity of antimicrobial use: the basicsDr. Paul van der Linden

14:00 – 15:00

Workshop “How to deduct Quantitative Measures
from a raw database and how to analyse and
present data

Dr. Paul van der Linden
Dr. Reinier van Hest          Dr. Nynke Jager


Workshop Implementation in practice (part IIb) “How do I measure the quality of antimicrobial use?”



Workshop Implementation in practice (part IIb) “How do I measure the quality of antimicrobial use?”


15:30 – 16:00

Quality Indicators in Antimicrobial Stewardship, the basics

Prof. Dr. Marlies Hulscher

16:00 – 17:00

Workshop “How to operationalize Quality indicators for appropriate antimicrobial use”


17:00 – 17:30

Performing a Point Prevalence Survey, the basics

Dr. Jaap ten Oever

17:30 – 18:30

Workshop “How to conduct a Point Prevalence Survey, interpret and present results”


Free evening



Changing therapy: escalation and de-escalation / IV oral switch

09:00 – 09:30

Markers of inflammation and infection: how to interpret (e.g. CRP, PCT, leukocytes)? Can they be used to tailor treatment duration?

Dr. Mark de Boer

09:30 – 10:00

(Rapid) microbiological diagnostics: how to interpret?

Prof. Dr. Bhanu Sinha

10:00 – 10:30

Benefits of early IV-oral switch: low hanging fruit in Antimicrobial Stewardship Programs

Prof. Dr. Jan Prins


11:00 – 11:45

Escalation and De-escalation practice: how to do this in daily practice?

Dr. Mark de Boer

11:45 – 12:30

Follow-up diagnostics in S. aureus bacteremia consultations

Dr. Kim Sigaloff

14:00 – 22:00

Social Event: Lunch on the go
Visit to Boerhaave museum in Leiden; boat tour and diner



Stopping therapy and discharge with therapy at home

09:00 – 09:30

Stopping antibiotics and duration of antibiotic therapy. Guidelines vs practice

Prof. Dr. Jan Prins

09:30 – 10:00

(Prolonged) Antibiotic prophylaxis in perioperative and medical settings

Dr. Mark de Boer

10:00 – 10:30

IV antimicrobial therapy at home: OPAT, drug options, controls and toxicity

Dr. Jaap ten Oever              Dr. Rogier van Hest              Dr. Paul van der Linden

Workshop Implementation in practice (part III) “How do I analyse barriers?”

11:00 – 11:30

Determinants of Antibiotic use

Dr. Jeroen Schouten

11:30 – 13:00Workshop “How to assess barriers and facilitators related to optimal antibiotic use” 

Workshop Implementation in practice (part IV) How to devise an intervention?

14:00 – 16:00

Workshop “How do I get from a barrier to a
potentially effective intervention”

Dr. Milou Fredrix (online)

16:00 – 18:00

Group work


Fire-side chat

Dr. Babette Rump



Special Patient Groups

9:00 –9:30

AMS in the immuno-compromised patient

Dr. Anke Bruns

9:30 – 10:00

AMS in the Emergency department

Dr. Teske Schoffelen

10:00 – 10:30

Pediatric AMS

Dr. Gerdien Tramper


11.00 -12.00


“Grande Finale” of the group projects

13:00 – 15:30

Plenary presentation of team projects to the complete group of experts & discussion


15:30 – 16:15

Closing remarks and certificate ceremony