Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Clinical Findings that Indicate the Significance of Streptococcal Infections
Discussion Leader: Kimberly Kline (University of Geneva, Switzerland)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Shiranee Sriskandan (Imperial College London, United Kingdom)
"Group A Strep: Extreme Clinical and Epidemiological Phenotypes"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Catherine Satzke (Murdoch Children's Research Institute, Australia)
"Effect of Influenza on Group A Streptococci in the Upper Respiratory Tract"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Luke Joyce (University of Colorado Anschutz Medical Campus, United States)
"Group B Streptococcus Glycolipids During Pathogenesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kristin Huse (Imperial College London, United Kingdom)
"Understanding and Exploiting Group A Streptococcal Anti-Chemotactic Proteases in Vaccines for Infection"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Approaches in Microbiology and Infection Biology
Discussion Leader: Victor Nizet (University of California, San Diego, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Roi Avraham (Weizmann Institute of Science, Israel)
"Characterizing Individual Host-Pathogen Encounters at Early Stages of Infection"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Tim van Opijnen (Boston Children's Hospital / Harvard Medical School, United States)
"Multidimensional Bacterial Profiles to Uncover Pathways to Resistance and Host-Immune Interactions"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Melanie Hamon (Institut Pasteur, France)
"NK Cells Sense and are Transcriptionally Reprogramed Following Streptococcus Pneumoniae Infection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Justin Kaspar (The Ohio State University College of Dentistry, United States)
"Techniques for Analyzing Single Cell Behaviors of Streptococci Within Biofilm Populations"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Carlos Orihuela (The University of Alabama at Birmingham, United States)
"Zinc Metalloproteinase B (ZmpB) Potentiates Cardiac Injury during Invasive Pneumococcal Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Michael Johnson (University of Arizona/NSURP, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rise of the Resistance: Evolution, Phages and Mobile Genetic Elements
Discussion Leader: Andrew Varble (University of Rochester, United States)
7:30 pm - 7:55 pm
Jean-Claude Sirard (Institut Pasteur de Lille - Inserm, France)
"Combining Antibiotic and Host-Directed Biologic in Pneumococcal Pneumonia: Impact on Efficacy and Antibiotic Resistance"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Lucy Weinert (University of Cambridge, United Kingdom)
"Antibiotic Cartography for the Visualization and Analyses of Beta-Lactam Resistance in Streptococci"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Nathalie Campo (Centre National de la Recherche Scientifique, France)
"Understanding the Mechanism of a Programmed Cell Growth Arrest During Competence for Transformation in Streptococcus Pneumoniae "
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Jun Kurushima (Gunma University, Japan)
"Plasmid-Encoded Bacteriolysin Promotes Horizontal Gene Transfer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host-Pathogen Interactions and Cellular Heterogeneity
Discussion Leader: Jason Rosch (St. Jude Children's Research Hospital, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Jorge Vidal (University of Mississippi Medical Center, United States)
"The Oxidation of Hemoproteins Facilitates Encapsulation of Pneumococci in the Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Partho Ghosh (University of California, San Diego, United States)
"Conserved 3D Patterns in M Proteins as Strep A Vaccine Immunogens"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Annelies Zinkernagel (University of Zurich, Switzerland)
"Stress Adaptation During Streptococcal Infections and Early Detection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Christopher LaRock (Emory University School of Medicine, United States)
"Immune Activation by the Group A Streptococcus Protease Virulence Factor SpeB"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
András Spaan (UMC Utrecht, The Netherlands)
"Human Genetic Determinants of Invasive Group A Streptococcal Host-Pathogen Interactions"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Reid Wilkening (University of Colorado, Children's Hospital Colorado, United States)
"A Skin-Deep Interaction? Modeling Acute Rheumatic Fever Via Intact Skin Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insights from Commensal Streptococci and Other Lactic Acid Bacteria
Discussion Leader: Jacqueline Kimmey (University of California, Santa Cruz, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Natalia Korotkova (University of Kentucky, United States)
"Disorder Regulates Homeostasis of Extracytoplasmic Proteins in Streptococci"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Hui Wu (Oregon Health & Science University, United States)
"Probing Oral Biofilms by Small Molecules"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Raquel Sa-Leao (Instituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa, Portugal)
"Crosstalk Between Commensal Streptococci and Streptococcus Pneumoniae"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kaylie Lam (University of Florida, United States)
"A Pentavalent Vaccine Targeting Surface Adhesins and Metal-Binding Lipoproteins Confers Robust Protection Against Enterococcal Infections"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Essential Cell Biology of Streptococci
Discussion Leader: Malcolm Winkler (Indiana University Bloomington, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Cecile Morlot (CNRS, France)
"Click and Collect in the Wall: Streptococcal Division at the Nanoscale"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Liselot Dewachter (UCLouvain, Belgium)
"Reverting Antibiotic Resistance in Streptococcus Pneumoniae: Targeting the Mevalonate Pathway to Potentiate Amoxicillin"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Lin Zeng (University of Florida, College of Dentistry, United States)
"Transcriptomic Overlap Between Fructose Metabolism and Methylglyoxal-Mediated Response in Streptococcus Mutans"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Bruno Lima (University of Minnesota, United States)
"The Role of the Proteins Acetyltranferase SktA in Streptococcus Gordini Physiology"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Zhe Ma (Nanjing Agricultural University, China)
"The PTSman System Promotes the Proliferation of Streptococcus Equi Ssp. Zooepidemicus in CSF by Preventing Stringent Response"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Madison Stellfox (University of Pittsburgh, United States)
"Daptomycin Tolerance in Vancomycin-Resistant Enterococcus Faecium from Patients with Recurrent Bloodstream Infections"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutics and Host Responses
Discussion Leader: Jacqueline Abranches (University of Florida, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Aras Kadioglu (Department of Clinical Infection, Microbiology & Immunology, University of Liverpool, United Kingdom)
"The Role of Carriage and Transmission in Pneumococcal Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Elaine Tuomanen (St. Jude Children's Research Hospital, United States)
"Pneumococcus Reveals an Innate Developmental Pathway Regulating Neuronal Proliferation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Pontus Nordenfelt (Lund University, Sweden)
"Discovery and Engineering of Protective Human Monoclonal Antibodies Against Group A Streptococci"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Streptococcal Ecology and Genomics
Discussion Leader: Kevin McIver (University of Maryland / Maryland Pathogen Research Institute, United States)
9:00 am - 9:25 am
Vaughn Cooper (University of Pittsburgh, United States)
"Experimental Evolution of S. Pneumoniae in Mice Defines Causes of Tissue Tropism, Drug Tolerance, and Immune Evasion"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Nicholas Croucher (Imperial College London, United Kingdom)
"Phage Strategies for Host Manipulation and Evasion of Recombination in Pneumococci"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Debra Bessen (New York Medical College, United States)
"Recombinational Exchange of M-Fibril and T-Pilus Genes Generates Extensive Cell Surface Diversity in the Global Group A Streptococcus Population "
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Andrew Hryckowian (University of Wisconsin-Madison, United States)
"Diet as a Tool to Understand Group B Streptococcus Gastrointestinal Colonization"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Claire Turner (University of Sheffield, United Kingdom)
"Genetic Diversity and Adaptation within Streptococcus Pyogenes Populations"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Lindsey Burcham (University of Tennessee, United States)
"GBS Navigation of Oxidative Stress in the Reproductive Tract"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Gene Regulation and Systems Biology
Discussion Leader: Jose Lemos (University of Florida, United States)
7:30 pm - 8:00 pm
Kelly Doran (University of Colorado School of Medicine, United States)
"The Fight for Survival by Group B Streptococcus in the Diabetic Wound: Finding the Sweet Spot"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:15 pm
Introduction by Discussion Leader
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure