The ESCMID Study Group for Implant-Associated Infections (ESGIAI) focuses on the challenges posed by implant-associated infections in clinical microbiology (CM) and infectious diseases (ID). Through a multidisciplinary approach, ESGIAI is committed to:
Come and join our upcoming Postgraduate Education Course
Implant infections: focus on prosthetic joint and fracture-related infections
05 -06 October 2026, online
ESGIAI Newsletter, July 2026
ESGIAI Newsletter, May 2026
ESGIAI Newsletter, February 2026
ESGIAI Newsletter, December 2025
ESGIAI Newsletter, November 2025
ESGIAI Newsletter, September 2025
ESGIAI Newsletter, July 2025
ESGIAI Newsletter, February 2025
Global practice variation of suppressive antimicrobial treatment for prosthetic joint infections: A cross-sectional survey study.
Hanssen JLJ, Gademan MGJ, Wouthuyzen-Bakker M, Davis JS, Dewar D, Manning L, Campbell D, van Prehn J, Miller AO, van der Wal RJP, van der Linden HMJ, Cortés-Penfield NW, Soriano A, de Boer MGJ, Scheper H. J Infect. 2024 Dec;89(6):106316
Risk Factors for Discordance Between Synovial Fluid Culture and Intraoperative Cultures in Revision Arthroplasties: Results From a European Multicentre Observational Study.
Ottink KD, Olearo F, Vaznaisiene D, Rolvien T, Kaoual S, Morreel E, Bîrluţiu V, Gómez-Junyent J, Lindberg-Larsen M, Reissier S, Rossi N, Dolores Del Toro Lopez M, Widerström M, Fernandez Sampedro M, Veltman ES, Petersdorf S, Rohde H, Wouthuyzen-Bakker M. JB JS Open Access. 2026 Apr 14;11(2):e26.00067
Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO bacteriology reference center network.
Bémer P, Plouzeau-Jayle C, Lemarié C, Tande D, Gougeon-Jolivet A, Chenouard R, Lamoureux C, Reissier S, Ruffier d'Epenoux L, Chaufour L, Lartigue MF, Corvec S; on behalf the CRIOGO study group. Ann Clin Microbiol Antimicrob. 2025 Nov 4;24(1):61
In vitro emergence of amoxicillin-resistance and impact of amoxicillin on biofilm production across Cutibacterium acnes phylotypes?
Ruffier d'Epenoux L, Rwayane K, Paquin A, Persyn E, Fayoux E, Hervochon C, Corvec S. Eur J Clin Microbiol Infect Dis. 2026 Apr;45(4):1213-1218. doi: 10.1007/s10096-025-05359-3. Epub 2026 Jan 4. Erratum in: Eur J Clin Microbiol Infect Dis. 2026 Apr;45(4):1219
Geographical Differences in the Epidemiology and Treatment of Candida Prosthetic Joint Infections.
Mamona-Kilu C, Lora-Tamayo J, McNally M, Duran C, Ho R, Scarborough M, Dudareva M, Bonnet E, Escolà-Vergé L, Pardo DR, Jesuthasan G, Senneville E, Thill P, Klein S, Ronde-Oustau C, Redó MLS, Corvec S, Rossi N, Esteban J, Lemaignen A, Ribeiro TC, Mazet J, Sasso M, Costa Salles MJ, Mancheño-Losa M, Giordano G, Frank BJH, Hofstaetter JG, Allende JMB, Lortholary O, Fourcade C, Morata L, Soriano A, Dinh A; European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI). Open Forum Infect Dis. 2026 Apr 15;13(4):ofag208
How to manage patients receiving long-term suppressive antibiotic treatment for infective endocarditis: the role of [18F]-FDG-PET/CT imaging - An international multidisciplinary survey.
Pascale R, Fernández-Hidalgo N, Tazza B, Bartoletti M, Bertolino L, Durante-Mangoni E, Pérez AR, Pizzi MN, Viale P, Giannella M; European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI); European Society of Clinical Microbiology and Infectious Diseases Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES). J Nucl Cardiol. 2025 Sep 27:102505
Bacterial skin colonization with a specific Cutibacterium avidum clade as a risk factor for periprosthetic joint infections—a multicenter study.
Salar Vidal L, Prinz J, Frey PM, Schweizer TA, Böni L, Brugger SD, Brüggemann H, Esteban J, Achermann Y, . 0. Microbiol Spectr 0:e00515-25.
Diagnostic accuracy of 16S rDNA PCR, multiplex PCR and metagenomic next-generation sequencing in periprosthetic joint infections: a systematic review and meta-analysis.
Olearo F, Zein SE, Portillo ME, Zapf A, Rohde H, Berbari EF, Wouthuyzen-Bakker M; ESCMID study group on implant-associated infections (ESGIAI) and the molecular working group for the unified PJI definition task force. Clin Microbiol Infect. 2025 Jul;31(7):1115-1125
Risk factors for treatment failure in late acute periprosthetic joint infection in patients with rheumatoid arthritis treated with surgical debridement - a case-control study.
Schenk HM, Sebillotte M, Lomas J, Taylor A, Benavent E, Murillo O, Fernandez-Sampedro M, Huotari K, Aboltins C, Trebse R, Soriano A, Wouthuyzen-Bakker M; ESCMID Study Group on Implant Associated Infections (ESGIAI). J Bone Jt Infect. 2025 Jul 14;10(4):217-224
Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.
Dinh A, McNally M, D'Anglejan E, Mamona Kilu C, Lourtet J, Ho R, Scarborough M, Dudareva M, Jesuthasan G, Ronde Oustau C, Klein S, Escolà-Vergé L, Rodriguez Pardo D, Delobel P, Lora-Tamayo J, Mancheño-Losa M, Sorlí Redó ML, Barbero Allende JM, Arvieux C, Vaznaisiène D, Bauer T, Roux AL, Noussair L, Corvec S, Fernández-Sampedro M, Rossi N, Lemaignen A, Costa Salles MJ, Cunha Ribeiro T, Mazet J, Sasso M, Lavigne JP, Sotto A, Canouï E, Senneville É, Thill P, Lortholary O, Lanternier F, Morata L, Soriano A, Giordano G, Fourcade C, Frank BJH, Hofstaetter JG, Duran C, Bonnet E; European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI). Prosthetic Joint Infections due to Candida Species: A Multicenter International Study. Clin Infect Dis. 2025 Feb 24;80(2):347-355
Treatment and Follow-up of Vascular Graft and Endograft Infection: Delphi Consensus Document.
Kouijzer, I. J. E., Hernández-Meneses, M., Aarntzen, E. H. J. G., Ahl, J., Baddour, L. M., DeSimone, D. C., Durante Mangoni, E., Fernández-Hidalgo, N., Geuzebroek, G. S. C., Giannitsioti, E., Glaudemans, A. W. J. M., Husmann, L., Merli, M., Mestres, C. A., Olearo, F., Papadimitriou-Olivgeris, M., Jørgensen, N. P., Perissinotti, A., Raglio, A., ... Hasse, B. (2025). Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.
Dinh A, McNally M, D'Anglejan E, Mamona Kilu C, Lourtet J, Ho R, Scarborough M, Dudareva M, Jesuthasan G, Ronde Oustau C, Klein S, Escolà-Vergé L, Rodriguez Pardo D, Delobel P, Lora-Tamayo J, Mancheño-Losa M, Sorlí Redó ML, Barbero Allende JM, Arvieux C, Vaznaisiène D, Bauer T, Roux AL, Noussair L, Corvec S, Fernández-Sampedro M, Rossi N, Lemaignen A, Costa Salles MJ, Cunha Ribeiro T, Mazet J, Sasso M, Lavigne JP, Sotto A, Canouï E, Senneville É, Thill P, Lortholary O, Lanternier F, Morata L, Soriano A, Giordano G, Fourcade C, Franck BJH, Hofstätter JG, Duran C, Bonnet E; European Society of Clinical Microbiology and Infectious Diseases Study Group on Implant Associated Infections (ESGIAI). Clin Infect Dis. 2024 Aug 27:ciae395
Prosthetic Joint Infections Caused by Mycobacterium tuberculosis Complex-An ESGIAI-ESGMYC Multicenter, Retrospective Study and Literature Review.
Auñon A, Salar-Vidal L, Mahillo-Fernandez I, Almeida F, Pereira P, Lora-Tamayo J, Ferry T, Souèges S, Dinh A, Escudero R, Menéndez Fernández-Miranda C, Rico A, Rossi N, Esteban J. Microorganisms. 2024 Apr 24;12(5):849
Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?
Rondaan C, Maso A, Birlutiu RM, Fernandez Sampedro M, Soriano A, Diaz de Brito V, Gómez Junyent J,Del Toro MD, Hofstaetter JG, Salles MJ, Esteban J, Wouthuyzen-Bakker M; ESCMID Study Group on Implant-Associated Infections (ESGIAI). Clin Microbiol Infect. 2023;S1198-743X(23)00345-2.
Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study)
Pascale R, Toschi A, Aslan AT, Massaro G, Maccaro A, Fabbricatore D, Dell'Aquila A, Ripa M, Işık ME,Kızmaz YU, Iacopino S, Camici M, Perna F, Akinosoglou K, Karruli A, Papadimitriou-Olivgeris M,Kayaaslan B, Bilir YA, Evren Özcan E, Turan OE, Işık MC, Pérez-Rodríguez MT, Yagüe BL, Quirós AM,Yılmaz M, Petersdorf S, De Potter T, Durante-Mangoni E, Akova M, Curnis A, Gibertoni D, DiembergerI, Scudeller L, Viale P, Giannella M; CarDINe Study Group. International Journal of Antimicrobial Agents. 2023;61(3):106734.
Should we use rifampicin in periprosthetic joint infections caused by Staphylococci when the implant has been exchanged? A multicenter observational cohort study.
Kramer TS, Soriano A, Tedeschi S, Chen AF, Tattevin P, Senneville E, Gomez-Junyent J, Birlutiu V,Petersdorf S, de Brito VD, Gonzalez IS, Belden KA, Wouthuyzen-Bakker M, on behalf of the ESCMID Study Group on Implant Associated Infections (ESGIAI). Open Forum Infectious Diseases. 2023;10(10):ofad491.
This page gives an overview of our planned and ongoing ESGIAI research projects.
Information how to join projects which are currently recruiting can be found at the bottom of the respective section.
DESIRE: Invitation to Participate in a Study on Dalbavancin as Suppressive Antibiotic Treatment
We are pleased to invite you to participate in a study investigating the use of Dalbavancin as suppressive antibiotic treatment. This is a retrospective, multicenter study supported by ESGIAI and endorsed by ESGIE groups from ESCMID. It focuses on all cases where Dalbavancin has been used as suppressive antibiotic treatment, apart from its original indication.
Scientific Committee:
Factors associated with infections by Multidrug-Resistant Pathogens in Neurosurgical Implants: A multicenter Retrospective Cohort Study
Primary Objective: To determine the prevalence of MDR pathogen infections in patients with neurosurgical implant-related infections
Secondary Objectives:
Lydia Leonidou, Efthymia Giannitsioti
PJI due Enterobacterales C3G resistant International retrospective multicentric study
Aim: Describe epidemiology, clinical presentation, treatment and outcome of PJI due to 3rdGC-resistant Enterobacterales
Scentific group
The Outcome of Surgical Debridement and Implant Retention in Patients With Periprosthetic Joint Infection of a Mega Prosthesis
Aims:
Principal Investigator. Marjan Wouthuyzen-Bakker (ESGIAI member)
A Unified Definition of Periprosthetic Joint Infection: EBJIS, ESGIAI, ICM, IDSA, MSIS
Principal Investigator: Marjan Wouthuyzen-Bakker
Methods
Publication expected soon
Evaluation of the risk of treatment failure in patients with fracture related infection. Multicenter study and proposal for a Fracture Related Infection Management ALgorithm (FRIMAL protocol).
Principal Investigators: María Dolores del Toro, Bouchra Dahiri, Raquel García Albea
Background: Management of FRI based on low-quality studies and expert opinion, more evidence is needed to support the medical-surgical management of these infections
Objectives
CAPJI: Current aetiology of joint prosthesis infections. How does it influence the empirical treatment of infections and the surgical prophylaxis of joint prosthesis implantation?
Principal Investigators: Anna Gallego, Natividad Benito
Objectives
Longterm antibiotic therapy in non-surgical prosthetic valve endocarditis. L-TAPE study
Principle investigators: Renato Pascale, Linda Bussini, Michele Bartoletti, Natascia Caroccia
Design: Retrospective, international, multicenter study
Population: All adult patients with diagnosis of definitive or possible left-sided PVE (Duke criteria) including TAVI-PVE not eligible for surgery during the period 2013-2025. Patients must have already received at least 4 weeks of standard treatment for PVE according to guidelines.
Definition: LTAT is defined as treatment for endocarditis lasting ≥6 weeks.
Primary endpoint: Composite outcome of death, relapse of positive blood cultures for index pathogen, septic embolization, heart failure at 360 days from PVE diagnosis.
Anaerobic PJI - narrative review of the microbiological aspects
Principal investigators. Holger Rohde, Elizabeth Moreel, Eugenia Portillio, Flaminia Olearo
Should antimicrobial prophylaxis in arthroplasty surgery be adapted for patients at high risk of resistant pathogens
Principal investigators. Natividad Benito, Corian Sadelier Francisco Almeida, Alessandro Russo, Rares Birlutiu
If you have questions or comments for our study group, we warmly invite you to contact us!
