25 November 2010

Dear Colleague,
The ESCMID PK/PD of Anti-Infectives Study Group (EPASG) is a newly formed ESCMID Study Group. The constitutional meeting was held at the 20th ECCMID in Vienna in April 2010. EPASG's first activity, in collaboration with the International Society of Anti-Infective Pharmacology (ISAP), was the post-ECCMID symposium on special PK/PD topics. The symposium took place on 13 April 2010 in Vienna. EPASG focuses on:

  • Pharmacokinetic/pharmacodynamic relationships
  • Improved dosing to optimise activity as well as minimising toxicity, and controlling the development of resistance in anti-infective agents.
The field of PK/PD has boomed over the last years as the importance of drug concentrations and dosing to prevent resistance has become more and more evident. Supported by basic in vitro and in vivo studies as well as clinical studies, PK/PD is now an integral part of anti-infective drug development as well as in establishing revised dosage regimens for known drugs that have been available for decades. The Study Group intends to encourage and coordinate basic and translational research projects as well as to improve patient care via complimentary educational activities. Additionally, EPASG will establish a platform for sharing expertise among European countries, other ESCMID study groups, European committees, regulatory agencies, and other societies such as the International Society of Anti-Infective Pharmacology (ISAP).
The organising committee has focused on planning and preparing for activities and has already coordinated a variety of projects several of which have been successfully completed. Of the ongoing projects, some will take over a year and with support organised and pursued by designated EPASG project leaders.

Enjoy our first Newletter and read about EPASG's activities.

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Go to to see the information on the EPASG Website.

EMA – Draft Guideline

Comments on EMA’s draft guideline, Guideline on the Evaluation of Medicinal Products indicated for Treatment of Bacterial Infections

Official Symposium at ECCMID/ICC 2011 in Milan

The symposium “Bridging the gap of innovation – What we all could do” has been selected for presentation at ECCMID/ICC, 7 - 10 May 2011 in Milan, IT.

Meet-the-Expert Session at ECCMID/ICC 2011 in Milan

EPASG Collaborates in the Meet-the-Expert Session "PK/PD for non-experts" at ECCMID/ICC 7 - 10 May 2011 in Milan, IT.

New Ways of Using Old and Coming Antibiotics - Development of Combination Therapies, Dosage and Cycling

EPASG Workshop chaired by Johan Mouton at the conference "Global Need for Effective Antibiotics-Moving towards Concerted Action", Uppsala, SE, 6 - 8 September 2010.

Forthcoming Publication - Protein Binding

A mini-review and consensus statement by EPASG in collaboration with ISAP concerning in vitro pharmacodynamic testing of protein binding of antibiotics has been submitted to a major journal.

Grant Application at EU FP7-HEALTH-2011

Members of EPASG carefully prepared and submitted an application for a two-stage grant: FP7-HEALTH.2011.2.3.1-1 investigator-driven clinical trials of off-patent antibiotics.

PK/PD symposium in Milan, IT, May 2011

This symposium will be held directly before or after ECCMID/ICC, 7 - 10 May 2011 in Milan, IT. Further info will be available soon at the EPASG website.

As you can see, EPASG is off to an ambitious, motivated, and effective beginning. If you are a PK/PD researcher, microbiologist, clinician, pharmacologist or pharmacist, we welcome you to join EPASG and become part of our group. Everyone who is interested in using anti-infectives in an optimal way is encouraged to join our activities to improve patient care.

To stay informed about our activities and the PK/PD field log in or register at the ESCMID website, go to “My profile” and tick the box for EPASG (in “specialities”).

To participate in our activities, please contact us directly:

Please spread the word and forward this newsletter to your colleagues who would be interested in EPASG’s mission and activities.

We appreciate any comments, suggestions, and contributions!

With our best wishes

The EPASG Executive Committee

Ursula Theuretzbacher (Chairperson)
Johan Mouton (Secretary)
Françoise Van Bambeke (Treasurer)


Forthcoming ESCMID Events

Biofilms in Nosocomial Fungal Infections
31 January - 1 February 2011
Paris, France

Improving Antibiotic Prescibing in Hospitals
4 - 6 March 2011
Belgrade, Serbia

Clinical Implications of Antimicrobial Susceptibility Testing
10 - 12 March 2011
Izmir, Turkey

Acute Infectious Encephalitis: Challenges in Clinical and Biological Diagnosis
30 March - 1 April 2011
Grenoble, France

ESCMID Conference on the Impact of Vaccines on Public Health
1 - 2 April 2011
Prague, Czech Republic

Basic Parasitology
11 - 15 April 2011
Ankara, Turkey

21st ECCMID/27th ICC
7 - 10 May 2011
Milan, Italy

Infections in Critically Ill Patients
21 May - 22 May 2011
Athens, Greece

Aspergillosis: from Allergy to Invasive Disease
25 May - 26 May 2011
Manchester, UK

Emerging Multidrug Resistance
6 - 7 June 2011
Paris, France

Invasive Fungal Infections: Controversies and Lessons from the Clinical Practice
23 - 24 June 2011
Saint Petersburg, Russia

10th ESCMID Summer School
2 - 9 July 2011
Treviso, Italy

ESCMID/SHEA Training Course in Hospital Epidemiology
3 - 6 September 2011   
Brunnen, Switzerland

Clinical, Diagnostic and Therapeutic Aspects of Opportunistic Protozoal Infections - Workshop
6 - 9 September 2011   
Barcelona, Spain

More ESCMID events

ESCMID Executive Office
P.O. Box 214
4010 Basel
Phone +41 61 5080 173
The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.
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