Presentations & Publications

2020

Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study.
Popescu CP, Florescu SA, Hasbun R, et al. J Clin Virol. 2020 doi: 10.1016/j.jcv.2019.104213.
A Prospective Cohort Study to Identify Clinical, Biological and Imaging Features That Predict Etiology of Acute Encephalitis
Le Maréchal M, Mailles A, Seigneurin A et al. Clin Infect Dis 2020 doi: 10.1093/cid/ciaa598.
Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy.
Ricci S, Grandgirard D, Masouris I et al. BMC Infect Dis2020; 20: 505. doi. 10.1186/s12879-020-05226-w.

2019

Herpes simplex virus encephalitis update.
Stahl JP, Mailles A. Curr Opin Infect Dis 2019;32:239-243. doi: 10.1097/QCO.0000000000000554.
Understanding central nervous system efficacy of antimicrobials.
Tattevin P, Solomon T, Brouwer MC. Intensive Care Med 2019;45:93-96. doi: 10.1007/s00134-018-5270-1.
Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.
Oddo M, Bracard S, Cariou A, et al. Ann Intensive Care 2019 doi: 10.1186/s13613-019-0523-x.
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.
Muri L, Le ND, Zemp J et al.J Neuroinflammation 2019 doi: 10.1186/s12974-019-1549-6.
Sex-based differences in the response to dexamethasone in bacterial meningitis: Analysis of the European dexamethasone in adulthood bacterial meningitis study.
Dias SP, Brouwer MC, van de Beek D. Br J Clin Pharmacol 2019. doi: 10.1111/bcp.14163.
Impact of pre-hospital antibiotic therapy on mortality in invasive meningococcal disease: a propensity score study.
Cabellos C, Pelegrín I, Benavent E, et al. Eur J Clin Microbiol Infect Dis 2019;38(9):1671-1676. doi: 10.1007/s10096-019-03599-8.
Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis.
Muri L, Perny M, Zemp J, et al. Antimicrob Agents Chemother 2019;63(7). pii: e00220-19. doi: 10.1128/AAC.00220-19.
Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study.
Popescu CP, Florescu SA, Hasbun R, et al. J Clin Virol. 2019 doi: 10.1016/j.jcv.2019.104213.
Long-term mortality and epilepsy in patients after brain abscess: A nationwide population-based matched cohort study.
Bodilsen J, Dalager-Pedersen M, van de Beek D, et al. Clin Infect Dis 2019. pii: ciz1153. doi: 10.1093/cid/ciz1153.

2018

Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis.
A systematic review and meta-analysis.
Rupprecht TA, Manz KM, Fingerle V, et al. Clin Microbiol Infect 2018;24:1234-1240. doi: 10.1016/j.cmi.2018.04.007
Novel and preclinical treatment strategies in pneumococcal meningitis.
Bewersdorf JP, Grandgirard D, Koedel U, Leib SL. Curr Opin Infect Dis 2018;31:85-92. doi: 10.1097/QCO.0000000000000416
Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis:
Results of the Ege study.
Sipahi OR, Mermer S, Demirdal T, et al. Clin Neurol Neurosurg 2018;172:31-38. doi: 10.1016/j.clineuro.2018.06.008.

ESCMID Postgraduate Course: Acute Bacterial CNS Infections of the Brain

11-13 October 2018, Munich, Germany

Acute CNS infections are still associated with high mortality and morbidity. Crucial factors for improving outcome are a quick diagnostic work-up, the swift start of empiric antibiotic treatment and, in pneumococcal meningitis, adjunctive therapy with dexamethasone. One important reason for the poor outcome is the frequent development of intracranial complications. In the postgraduate education course “acute bacterial CNS infections of the brain”, the first focus will be on the diagnostic work-up of patients with suspected CNS infections. The second focus will concentrate on the therapeutic management and, finally, the participants will learn how to deal with intracranial complications in CNS infections. The majority of the session will take place in groups under the guidance of expert senior physicians on CNS infections. This setting will ensure an intense and interactive teaching atmosphere.

2017

An update on bacterial brain abscess in immunocompetent patients. Sonneville et al., CMI 2017; Sep 23(9): 614-620

A brain abscess is a focal infection of the brain that begins as a localized area of cerebritis. In immunocompetent patients, bacteria are responsible for >95% of brain abscesses, and enter the brain either through contiguous spread following otitis, sinusitis, neurosurgery, or cranial trauma, or through haematogenous dissemination. Brain abscess has complex diagnostic challenges and potentially severe consequences. The aim of the authors of this review, experts in infectious diseases, intensive care, microbiology, neurosurgery and imaging, was to take into consideration the multidisciplinary nature of the disease; in 2017, they reviewed the state-of-the art for brain abscess, focusing on immunocompetent patients and putting special emphasis on recent papers. This review is structured in different chapters giving update on pathogenesis, epidemiology, diagnosis, neurosurgery, microbiology, antibacterial treatment and symptomatic measures

ESGIB session at ID week 2017

A Case Based Approach to Guidelines: Meningitis, Encephalitis, and Nervous System Lyme Disease

The aim of this session was to describe diagnostic approaches and patients management for meningitis, encephalitis and nervous system Lyme disease. Key features listed in the guidelines were highlighted.

Moderators: Jean-Paul Stahl andAdarsh Bhimraj

Speakers: Diederik van de Beek, Christina Marra, John Halperin