Date: 5-6 September 2022

 

Location: Geneva, Switzerland

 

Organiser

 

Paediatric working group, ESCMID Study Group for Antimicrobial Stewardship (ESGAP)

 

Module objectives

 

Although providing advice on the management of children with infections (both common and complex infections) falls within the routine workload of clinical microbiologists and antimicrobial pharmacists working in general hospitals across Europe, there are many fundamental differences between adults and children that impact on decision making. Not only are children vulnerable to a number of pathologies that most adults are protected from, the aetiology and presentation of infection in children often differs considerably. Sample collection in children can be extremely challenging and the effect of the microbiota can limit the utility of many tests in children. For these reasons, many microbiologists and clinical pharmacists feel less confident proving advice on children compared to adults, potentially resulting in unnecessary investigations, prolonged exposure to antimicrobials and diagnostic delays. This course aims to address some of these issues through a series of case-based interactive workshops. Active participation will be maintained through on-line discussions and real-time voting. Key differences between children and adults will be highlighted and evidence based approaches to managing children will be presented. Discussions within these workshops will include the role of lumbar puncture in young infants with UTIs, conservative versus surgical management of atypical mycobacterial lymphadenitis in children, the role of pneumococcal urinary antigen testing in children with pneumonia, whether routine echocardiography is required in all children with staph aureus bacteraemia, investigating the baby with late onset sepsis, managing children following a significant exposure to pulmonary TB and many others. This approach has been used annually at the annual UK Federation of Infection Society (FIS) meeting and has received excellent feedback from microbiologists.

 

Preliminary programme

 

Programme flyer

 

Date: 23-25 January 2023

 

Location: Online

 

Organisers

 

Bichat Claude Bernard Hospital, University of Paris, IAME, Inserm; in partnership with Doctors Without Borders (MSF), Imperial College London, United Kingdom, University of Cape Town, South Africa and University of Bobo Dioulasso, Burkina Faso

 

Module objectives

 

Understand the issues and challenges of AMS in LMICs, to enable participants to better adapt the concepts learned in the other modules to these specific contexts, based on the example of several specific initiatives and solutions. The module will cover three themes: the context (Epidemiology of AMR and Antimicrobial prescription in LMICs); the implementation of AMS programs in LMICs; and the perspectives (researches, innovations, and training programs). This is aimed either at participants wishing to practice directly in these fields, or at those working on global health issues.

 

Preliminary programme

 

Programme flyer

 

Date: 17-19 March 2023

 

Location: Homburg/Saar, Germany

 

Organisers

 

Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany

 

Module objectives

 

Processes of globalisation and climate change have far-reaching consequences, which affect medical care worldwide. Steadily rising temperatures and climate change-induced natural disasters lead to changing mobility patterns and migration movements of refugees. Furthermore, infectious diseases may become prevalent in regions that have not been affected previously. Antimicrobial stewardship, especially for migration- and travel-associated infections, should therefore be taught with a global and holistic perspective, taking medical, political, and cultural factors into account. The aims of the course are to (i) enable participants to diagnose and classify infectious diseases in the context of travel and migration, (ii) develop diagnostic strategies and treatment options for selected travel- and migration-associated infections, and (iii) apply the AMS concept specifically to health problems associated with migration, One Health and climate change.

 

Preliminary programme

 

Programme flyer

 

Date: 10-12 May 2023

 

Location: Seville, Spain

 

Organisers

 

Hospital Universitario Virgen Macarena

 

Module objectives

 

1. To learn how an antimicrobial stewardship programme (ASP) was designed

and implemented in a specific setting (University hospital with a low rate of multidrug-resistant

organisms [MDRO] located in Southern Europe)

 

2. To observe and learn how the ASP interventions are performed in real life in the different clinical settings and scenarios, with the

available resources

 

3. To discuss how to measure the impact of the interventions

 

4. To understand the importance of the synergy between infection control and ASP

 

Preliminary programme

 

Programme flyer

 

Date: 25-26 May 2023

 

Location: Poitiers, France

 

Organisers

 

University hospital of Poitiers / University hospital of Lille

 

Module objectives

 

The aim of the module is to ensure an understanding of:

 

  • Pharmacokinetics: knows and understands the pharmacokinetics of antibiotics related to AMS
  • Extracellular/intracellular distribution of antimicrobials and its implication for antibiotic prescribing
  • Pharmacodynamics: knows the mechanism of action of antimicrobials, their clinically relevant antimicrobial spectra, and understands the pharmacodynamics properties important for antimicrobial dosing
  • Allergy: knows and understands the pathogenesis of allergy to antimicrobials and its clinical presentation, and can plan the therapy to avoid the risk of allergy, knows the principles of de-labelling and as a leader be capable of organizing de-labelling in their setting
  • Availability of antimicrobials: knows the antimicrobials listed in the formulary in his setting and their trade names, contributes to proper inclusion of new antimicrobial drugs in the formulary, knows the risks of drug shortages and is capable to respond to the shortages according to the setting
  • The dose / dosing interval (incl. prolonged and continuous infusion): understands the benefits and risks of dosing schedules, can plan appropriate dosing schedules, and is able to explain them to the primary team and the patient
  • Dosing in renal failure, during various renal replacement therapies and during extracorporeal membrane oxygenation, in nebulizators
  • Knows how to adjust the dose of antimicrobials according to the changes in pharmacokinetic of antibiotics related to the patient condition (decreased renal and hepatic function, severe burns, oedema, etc.)
  • Therapeutic drug monitoring (TDM): understands the need for TDM, knows how the interpret the results, and as a leader is capable of organizing TDM in the setting
  • Knows and understands the statistical methods for the analysis of AMS interventions
  • Knows the IT resources available outside the workplace that may be useful for AMS and knows how to use them
  • Knows how to use IT support available in the setting to monitor and improve antimicrobial use
  • Knows and understands the use of information technology in surveillance, medication management, and AMS interventions (education, restrictions, drug approval)
  • Knows and understands the use of electronic clinical decision support, telehealth, and smartphone apps in antibiotic prescribing and AMS
  • Understands the benefits of computerized medical records including computerized prescribing of antimicrobials and contributes to the development and use of the programs

 

Preliminary programme

 

*This module programme is subject to minor amendments

 

Day 1

09:00 - 09:15

Welcome

09:15 - 11:00

Basic principles of PK/PD

François Jehl

11:00 - 11:20

Pause

11:20 - 12:00

Optimized PK/PD as a tool for AMS

Jason A. Roberts

12:00 - 13:30

Lunch

13:30 - 14:00

Modelling principles in antibiotics PK/PD

Femke de Velde

14:00 - 14:20

Antimicrobial dosing optimisation and kidney failure

Emmanuel Faure

14:20 - 15:20

Practical exercise on dose optimization

TBD

15:20 - 15:40

Antimicrobial dosing optimisation in specific populations, in particular immunocompromised patients

Emmanuel Faure

15:40 - 16:00

Information technology as a tool for antimicrobial stewardship (including shortages)

Guillaume Beraud

16:00 - 16:30

A comprehensive review of IT resources for AMS

Tim Rawson

16:30 - 16:50

Pause

16:50 - 17:10

A practical example of IT implementation for AMS,

Louis Valiquette

17:10 - 17:30

Big data to tackle AMR

Philippe Desprez

17:30 - 18:30

Practical exercise: Data science for antimicrobial stewardship

Christian Luz

19:00

Dinner and social event

 

Day 2

09:00 – 09:15

Welcome

Guillaume Beraud and Emmanuel Faure

09:15 – 11:00

Statistical methods to assess AMS interventions

Lander Willem

11:00 – 12:00

Practical exercise on analysing data

 

12:00 – 12:30

Antimicrobial allergy: Diagnostic and de-labelling as a tool for AMS

 

12:30

Lunch and conclusions of the seminar

 

Programme coordinator contact

 

Guillaume Beraud

 

University Hospital of Poitiers,

 

France

 

Date: October 2023

 

Location: Online

 

Organisers

 

Faculty of medicine, University Ss Cyril and Methodius Skopje & Institute for Social Innovation - Skopje

 

Module objectives

 

1. Recognizes problems that should be addressed in outpatient setting and is capable for addressing them by organizing appropriate structures, interventions, and monitoring

2. Understands the role of cultural and behavioral determinants in antibiotic prescribing in outpatient and primary care

3. Can recognize the facilitators and barriers to ASPs and is able to address them

4. Understands and can perform different communication techniques

5. Can communicate with all stakeholders involved in AMS at primary care level

 

Preliminary programme

 

Programme flyer

 

Date: TBD, 2024

 

Location: Online

 

Organisers

 

ESCMID PK/PD of Anti-Infectives Study Group (EPASG), The European Committee on Antimicrobial Susceptibility Testing (EUCAST), The International Society of Anti-Infective Pharmacology (ISAP)

 

Module objectives

 

This course presents and summarises currently available knowledge on PK/PD of

commonly used antibiotics, strategies for setting clinical breakpoints, individualised dosing, and

therapeutic drug monitoring. The aim is to provide participants with insights that can be used to

optimise antibiotic therapy for different patient groups, infection sites and pathogens.

 

Preliminary programme

 

*This module programme is subject to minor amendments

 

Day 1

8:15-8.30

Registration

8.30-8.40

Welcome and introduction 

08:40-9:25

Basics of dosing (interactive) 

09:25-10.30

Why do we need to reconsider standard dosing regimens – dosing in special patient populations

10:30-11:00

Break

11:00 -11:45

Current strategies for MIC determination and setting clinical breakpoints

11:45-12:15

Population PK modelling for individualised dosing

12:15-13:15

Lunch

13:15-14:15

Preclinical infection models and what are the experimental and clinical data

supporting PK/PD targets? (Thomas

supporting PK/PD targets?

14:15- 14:45

Mathematical modelling of preclinical data to predict dosing strategies

14:45 -15.00

Break

15:00- 15.45

Optimal dosing and continuous or prolonged infusion of beta-lactams and vancomycin – what is the evidence?

15.45-16.30

How to optimise the use of aminoglycosides, quinolones and polymyxins; use of therapeutic drug monitoring (clinical case studies, interactive) 

Day 2

08:30-09:00

Optimised dosing regimens for antibiotic combinations 

09:00-09:45

Impact of tissue penetration and when should local administration of antibiotics be consisidered?

9:45-10:15

Principles of individualised dosing of antifungals based on therapeutic drug monititoring

10:15-10:45

Break

10:45-11:15

Using decision support systems for dosing of anti-infectives – chances and caveats

11:15-12:00

How to apply knowledge on PK/PD and TDM in clinical practice (interactive)

12:15-13:30

Lunch

13.30-14.15

How to apply knowledge on PK/PD and TDM in clinical practice (continued)

14.15-15:00

Future perspectives – clinical breakpoints and dosing in 20 years? 

15:00-15:30

Break

15.30-16:00

Closing remarks and any remaining questions 

 

Programme coordinator contact

 

Markus Zeitlinger

Medical University of Vienna,

 

Vienna,

Austria

 

 

 

 

Date: 5-6 April 2024

 

Location: Online

 

Organisers

 

Aster Medcity

 

Module objectives

 

At the end of the course, the participant will be able to:

- Understand the basics and need for AMS in their setting

- Develop and implement a AMS program relevant to their setting

 

Preliminary programme

 

*This module programme is subject to minor amendments

 

Day 1

 

 

Epidemiology of MDRO in LMIC setting

 

30 min

 

Dr Sneha Radha MD 
Empiric Therapy in MDRO endemic setting - Clinical Syndrome based approach

90 min

Dr Anup R Warrier FRCP, FIDSA 

Impact of MDRO endemicity on surgical prophylaxis

30 min

Dr Dipu T S (MD )
Targeted Therapy in MDRO endemic setting - Pathogen based approach

90 min

Dr Sneha Radha MD 

Day 2

 

 
Barriers and Drivers of AMSP in LMIC settings

30 min

Dr Merlin MD 
Strategies for AMSP Implementation in high MDRO endemicity under resource poor settings

30 min

Dr Arun Wilson MD 
Strategies for AMSP Implementation in high MDRO setting under resource rich setting

30 min

Dr Ravikant Porwal MD 
Rapid Diagnostics of HRMO in high endemic setting - Impact on AMSP

30 min

Dr Arun Wilson MD 
Antifungal Stewardship - Challenge of Candida auris 30 min Dr Merlin MD 
AMSP in high MDRO endemicity settings - An overview 30 min Dr Anup R Warier FRCP FIDSA

 

Programme coordinator contact

 

Dr Anup R Warrier

Aster Medcity

 

Kerala,

 

India