Research & Projects

ESCMID Panorama

ESCMID Conference on Reviving Old Antibiotics

22 - 24 October 2014, Vienna, Austria

Final Scientific Programme

Download the pdf version of the Final Programme here.

 

Wednesday, 22 October 2014

08:30 - 10:10 h: Setting the scene

Chairs: Murat Akova & Ursula Theuretzbacher

08:30 - 08:40Welcome, introduction, opening of the conferenceMurat Akova, Turkey
08:40 - 09:10Reviving old antibiotics - a public health need Dominique L. Monnet, ECDC
09:10 - 09:40Usage of old antibiotics now and in the future Johan W. Mouton, Netherlands
09:40 - 10:10Ethical dilemmas when using old antibiotics Leonard Leibovici, Israel
10:30 - 12:30 h: Optimisation of therapy - general principles

Chairs: Alasdair Mac Gowan & Keith Kaye

10:30 - 11:00 Translational basic research for old antibiotics: What is lacking? Alasdair MacGowan, United Kingdom
11:00 - 11:30Optimisation of dosing regimens, dosing in special populations, duration of therapy Jason Roberts, Australia
11:30 - 12:00Optimised usage to prevent emergence of resistance and co-selection processes Vincent H. Tam, United States
12:00 - 12:30Combination therapy - The solution to all problems?Keith Kaye, United States
13:45 - 15:25 h: Optimisation of therapy in Gram-negative infections

Chairs: Roger Nation & Françoise Van Bambeke

13:45 - 14:00TemocillinFrançoise van Bambeke, Belgium
14:00 - 14:15Fosfomycin ivMatthew E. Falagas, Greece
14:15 - 14:30Fosfomycin TrometamolAngela Huttner, Switzerland
14:30 - 14:45NitrofurantoinAnouk E. Muller, Netherlands
14:45 - 15:00MecillinamNiels Frimodt-Møller, Denmark
15:00 - 15:15Chloramphenicol Noa Eliakim, Israel
15:15 - 15:25Discussion
15:45 - 17:10 h: Optimisation and individualisation of therapy

Chairs: Niels Frimodt-Møller & Angela Huttner

15:45 - 16:10ColistinRoger Nation, Australia
16:10 - 16:30TDM of old antibiotics - ColistinWilliam Couet, France
16:30 - 16:40Discussion
16:40 - 17:10Clinical decision making - strategies for individual patientsGeorge L. Daikos, Greece
17:10 - 17:30Summary of the first day                                                                                                                      

Thursday, 23 October 2014

08:30 - 10:00 h: Extending the life of old antibiotics

Chairs: Inge C. Gyssens & Mical Paul

08:30 - 09:00Resistance epidemiology and trends in old antibioticsChristian G. Giske, Sweden
09:00 - 09:30Impact of resistance on bacteria and epidemiological implicationsDan Andersson, Sweden
09:30 - 10:00Stewardship aspects for last resort antibioticsInge C. Gyssens, Netherlands
10:30 - 12:00 h: Clinical trials

Chairs: Leonard Leibovici & John D. Turnidge

10:30 - 11:00How do you “re-develop” an old antibiotic: experience from AIDA Ursula Theuretzbacher, Austria
11:00 - 11:30Strength and limitations of industry vs. academic randomised controlled trialsPierre-Francois Laterre, Belgium
11:30 - 12:00Observational studies vs. randomised controlled trialsMical Paul, Israel
13:00 - 15:00 h: Breakpoints and susceptibility testing

Chairs: Johan Mouton & Rafael Cantón

13:00 - 13:30ECOFFs for the early detection of resistance developmentGunnar Kahlmeter, Sweden
13:30 - 14:00Susceptibility testing issues with old antibiotics  John D. Turnidge, Australia
14:00 - 14:30Drawbacks of available breakpointsRafael Cantón Moreno, Spain
14:30 - 15:00Correlations of clinical outcomes and antimicrobial susceptibility testing resultAlex Soriano, Spain
15:30 - 17:05 h: Regulating and communicating new knowledge

Chairs: Gunnar Kahlmeter & Christian G. Giske

15:30 - 15:55

Re-evaluating and revising of existing indicationsMair Powell, United Kingdom
15:55 - 16:20Keeping up-to-date, regulatory issues: EMARadu Botgros, United Kingdom
16:20 - 16:40Dealing with old drugs - the industry's perspectiveHolger von Fircks, Sweden
16:40 - 17:05Organising and communicating changesof knowledge to the medical communictyOtto Cars, Sweden
17:20 - 17:50 h: Late breaker presentations: national and international actions

Chair: Otto Cars

17:20- 17:30MSF: relevance of old antibiotics in developing countriesChristophe Perrin, Switzerland
17:30- 17:40WHOCharles Penn, Switzerland
17:40- 17:50Governmental action - example SwedenCharlotta Edlund, Sweden

Friday, 24 October 2014

08:30 - 10:30 h: Round table discussion

Chairs: Ursula Theuretzbacher & Gunnar Kahlmeter

Within preceding sessions key issues will be identified to be discussed among panel members and the audience. Solved and unsolved problems with old antibiotics in the following areas:
  • Preclinical and clinical studies
  • Stewardship
  • Preserving efficacy
  • Breakpoints
  • Regulatory and industry perspectives
  • Bringing new knowledge to the clinician
10:50 - 12:20 h: Consensus session

Chairs: Ursula Theuretzbacher & Gunnar Kahlmeter

Discuss and agree on need for action. Input from the audience will be highly appreciated!
12:20 - 12:30 h: Conclusion and closing of the conference