Profession & Career

ESCMID Panorama

Diagnosis and Management of Drug-Resistant Tuberculosis, ESCMID Postgraduate Technical Workshop

18 - 19 January 2016, Cape Town, South Africa

  • University of Cape Town, South Africa
  • National Health Laboratory Services, South Africa
  • ESCMID Study Group for Mycobacterial Infections (ESGMYC)

Course Coordinators

  • Marc Mendelson, Cape Town, South Africa
  • Mark Nicol, Cape Town, South Africa
  • Widaad Zemanay, Cape Town, South Africa

Course Objectives

The aim is to develop a detailed understanding of the laboratory detection and characterization of drug resistance as well as the clinical management of drug-resistant tuberculosis and the interpretation of diagnostic tests used in clinical practice.

Course Venue

Faculty of Health Sciences
University of Cape Town
Cape Town, South Africa


Protea Hotel Breakwater Lodge
Portswood Road, V & A Waterfront
Cape Town, South Africa

Phone +27 214 061 911

Target Audience

15 – 20 young clinical microbiologists, infectious diseases specialists and technicians with an interest in drug-resistant M. tuberculosis, who want to get
an updated overview of the theoretical and practical aspects of diagnosis and management of drugresistant tuberculosis.

Contact Person (Scientific Programme)

Mark Nicol
5.28 Falmouth Building
Faculty of Health Sciences
Anzio Road, Observatory
7925 Cape Town
South Africa

Phone +27 214 066 727
Fax +27 214 066 210

Administrative Secretariat

Widaad Zemanay
5.16 Falmouth Building
Faculty of Health Sciences
Anzio Road, Observatory
7925 Cape Town
South Africa

Phone +27 214 066 727
Fax +27 214 066 210

Course Programme


Presentations are availabe in the ESCMID Online Lecture Library.


Monday, 18 January 2016: Laboratory detection of drug resistance


Demonstrations of laboratory tests for drug resistance, including genotypic (line probe assay, Xpert MTB/RIF, rpoB gene sequencing) and phenotypic (MGIT) methods. Discussion of the interpretation of complex results including heteroresistance, discordant results, low level resistance and the role of MIC testing.


  • The global epidemiology of drug-resistant tuberculosis. Helen Cox
  • The genetic basis of drug resistance in tuberculosis. Rob Warren
  • Strategy in providing microbiological data for a DST-tailored therapeutic regimen in MDR/XDR-TB. Emmanuelle Cambau
  • Understanding and resolving discordant laboratory results. Mark Nicol & Natalie Beylis
  • Whole genome sequencing for identification of drug resistance. Nazir Ismael

Tuesday, 19 January 2016: Clinical management of drug-resistant tuberculosis


Interactive cases will be presented to gain understanding of management issues surrounding MDR-TB and XDR-TB therapy, options for substitution when
one or more drugs are contraindicated, management of HIV coinfection, drug-drug interactions, adverse events and monitoring in DR-TB treatment.


  • Interpreting diagnostic tests for tuberculosis at the bedside. Tom Boyles
  • The drug pipeline & new paradigms for TB drug trials. Rodney Dawson
  • Pharmacokinetics and pharmacodynamics for optimal dosing in therapy for drug-resistant tuberculosis. Helen McIlleron
  • Treatment and prevention of paediatric MDR-TB. Simon Schaaf
  • TB consillium for MDR/XDR-TB cases. Christoph Lange
  • Severe adverse reactions to second line tuberculosis drugs: how to substitute and rechallenge. Graeme Meintjes
CME Accreditation

The course was granted 11 European CME credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME).

Faculty Members
  • Natalie Beylis, Cape Town, South Africa
  • Tom Boyles, Cape Town, South Africa
  • Emmanuelle Cambau, Paris, France
  • Helen Cox, Cape Town, South Africa
  • Rodney Dawson, Cape Town, South Africa
  • Nazir Ismael, Johannesburg, South Africa
  • Christoph Lange, Borstel, Germany
  • Helen McIlleron, Cape Town, South Africa
  • Graeme Meintjes, Cape Town, South Africa
  • Marc Mendelson, Cape Town, South Africa
  • Mark Nicol, Cape Town, South Africa
  • Simon Schaaf, Cape Town, South Africa
  • Rob Warren, Cape Town, South Africa
Last update: 20 April 2016

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Get the Course Leaflet as pdf.