Population Modelling and Dose Optimization with Pmetrics and BestDose: Antimicrobial Applications, ESCMID Postgraduate Technical Workshop

13 - 15 April 2016, Lyon, France

  • ESCMID PK/PD of Anti-Infectives Study Group (EPASG)
  • University Claude Bernard, Lyon, France
  • University of Seville, Seville, Spain
  • University of Liverpool, Liverpool, United Kingdom
  • Laboratory of Applied Pharmacokinetics and Bioinformatics (LAPKB), Los Angeles, CA, United States
  • University of Southern California (USC), Los Angeles, CA, United States
  • Children’s Hospital, Los Angeles, CA, United States
  • University of Queensland, Brisbane, Australia
Course Coordinators
  • Fernando Docobo-Pérez, Seville, Spain
  • Sylvain Goutelle, Lyon, France
Course Objectives
  • Define PK structural models that can be solved analytically and models that require differential equations
  • Create PK datasets appropriate for population analysis
  • Fit models to data to estimate population and individual distributions of model parameter values
  • Make and customize pharmacometric plots, including but not limited to model parameter joint densities, model diagnostics, and individual or population observations and predictions
  • Perform basic and Monte Carlo simulations for PK-PD analysis of antimicrobials in relevant software packages
  • Optimize dosing for an individual patient using nonparametric, multiple-model Bayesian adaptive control
Course Venue

School of Medicine and Pharmacy
University Claude Bernard Lyon 1
Rockefeller campus
8 avenue Rockefeller
69373 Lyon cedex 08

Target Audience

Up to 30 physicians, pharmacists, clinical microbiologists/toxicologists and biomedical scientists or trainees with an interest in pharmacometrics.

Please find more information about the event venue, transportation and accommodation in this document.

Contact Person (Scientific Programme)

Sylvain Goutelle
Service Pharmacie, Hôpital Pierre Garraud
Hospices Civils de Lyon
136 rue du Commandant Charcot
69005 Lyon

Phone +33 472 168 099
Fax +33 472 168 102

Administrative Secretariat

Fernando Docobo-Pérez
Departamento de Microbiología
Facultad de Medicina
Universidad de Sevilla
Avda. Sánchez Pizjuán s/n.
41009 Seville

Phone +34 655 407 371
Fax +34 954 377 413

Course Programme


Presentations are availabe in the ESCMID Online Lecture Library.

Wednesday, 13 April 2016

09:00 Review of pre-workshop tutorial. William Hope
10:00 Fitting data to models in Pmetrics. Jason Roberts
12:00 Lunch
13:30 Details and plotting of Pmetrics objects made during a run. Timothy Felton
15:00 Pmetrics modeling exercises with tutors. All faculty members
17:30 Adjourn

Thursday, 14 April 2016

09:00 Simulating and probability of target attainment with Pmetrics. Fernando Docobo-Pérez
10:30 Simulation exercises with tutors. All faculty members
12:00 Lunch
13:30 Understanding how BestDose works and the 3 modes. Michael Neely
14:30 Using BestDose stand-alone. Sylvain Goutelle
15:30 BestDose exercises with tutors. All faculty members
17:30 Adjourn

Friday, 15 April 2016

09:00 Using BestDose in R and on the web. Michael Neely
10:30 BestDose server exercises with tutors. All faculty members
12:00 Lunch
13:30 Closing and certificates of attendance
14:00 Staff available for questions or work on your own data

Faculty Members
  • Ghaith Aljayyoussi, Liverpool, United Kingdom
  • Fernando Docobo-Pérez, Seville, Spain
  • Timothy Felton, Liverpool, United Kingdom
  • Sylvain Goutelle, Lyon, France
  • William Hope, Liverpool, United Kingdom
  • Michael Neely, Los Angeles, CA, United States
  • Virginia Ramos Martin, Liverpool, United Kingdom
  • Jason Roberts, Brisbane, Australia
  • Jean Baptiste Woillard, Limoges, France

CME Accreditation

The event was granted 15 European CME credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME).