Evangelos J. Giamarellos-Bourboulis born 1971 in Athens, Greece; MD, PhD, Assistant Professor of Internal Medicine and Infectious Diseases at the University of Athens, Medical School, Greece, in recognition of his outstanding achievements in immunomodulatory therapy of Gram-negative sepsis with clarithromycin.
Evangelos Giamarellos-Bourboulis’s main research interests are immunopathogenesis and treatment of sepsis and the application of biomarkers in diagnosis and follow-up of sepsis. He earned his PhD in February 1998 with the thesis title, ‘The in vitro activity of polyunsaturated fatty acids on Gram-negative bacteria’, and since then he established two novel animal models of Gram-negative infections; one of bacteraemia and another of pyelonephritis. He built on them to demonstrate the successful role of intravenously administered clarithromycin for the immunomodulation of sepsis by multidrug-resistant bacteria. Based on his findings, he conducted a randomized clinical trial with the intravenous administration of clarithromycin in patients with nosocomial sepsis due to ventilator-associated pneumonia. Results revealed earlier resolution of pneumonia, earlier de-intubation and reduction of risk of death due to septic shock and multiple organ dysfunction.