Young Investigator Awardees 2008
William Hope born 1969 in Alice Springs, Australia; MBBS, FRACP, FRCPA, PhD, Senior Research Fellow in the Department of Medicine at the University of Manchester, in recognition of his outstanding achievements in the field of pathogenesis, diagnosis and treatment of fungal infections. He most successfully combines basic and clinical research and covers a large range of topics including genetic sequencing, molecular diagnostics, animal models and therapeutic management of fungal infection, applying a range of pharmacodynamic and pharmacokinetic modelling techniques.
William Hope's research has focused on identifying antifungal dosages and schedules which are associated with optimal therapeutic outcomes in humans. Antifungal PK-PD is a relatively young field, which explores the relationship between drug exposure and the antifungal effect. PK-PD is increasingly used in the development of new antimicrobial agents. Concentration-effect relationships are often best defined in experimental systems, in which the interaction between antifungal compounds, immunological effectors and clinically relevant biomarkers can be studied. The clinical implications of the experimental data can be explored using population pharmacokinetics and Monte Carlo simulation techniques. This paradigm can be used to identify antifungal dosages and schedules which are likely to be associated with optimal efficacy in humans, thereby facilitating the design of clinical trials likely to yield informative results and maximizing the use of limited resources.