Profession & Career

ESCMID Panorama

Latest publications funded by Research Grants

ESCMID is highlighting here the outcomes of Reseach Grant projects and acknowledges the accomplishments of our Grantees.

Highlighted articles 2016

Transmission between archaic and modern human ancestors during the evolution of the oncogenic human papillomavirus 16. Pimenoff VN, Mendes de Oliveira C, Bravo IG. Mol Biol Evol (2016); doi:10.1093/molbev/msw214

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This work has been (co-)funded by an ESCMID Research Grant 2015 to Ville N. Pimenoff, Barcelona, Spain.

Posttreatment antifungal resistance among colonizing Candida isolates in candidemia patients: results from a systematic multicenter study. Jensen RH, Johansen HK, Søes LM, Lemming LE, Rosenvinge FS, Nielsen L, Olesen B, Kristensen L, Dzajic E, Astvad KMT, Arendrup MC. Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1500-1508
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This work has been (co-)funded by an ESCMID Research Grant 2013 to Rasmus H. Jensen, Copenhagen, Denmark.

Further articles published in 2016

  • Cellular entry of the porcine epidemic diarrhea virus. Li W, van Kuppeveld FJ, He Q, Rottier PJ, Bosch BJ. Virus Res. 2016 Jun 15. pii: S0168-1702(16)30219-2. doi: 10.1016/j.virusres.2016.05.031
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    This work has been (co-)funded by an ESCMID Research Grant 2015 to Jan-Berend Bosch, Utrecht, Netherlands.
  • Co-infection with three linezolid-resistant Enterococcus faecium ST117 strain variants: what are we missing in diagnosis? Freitas AR, Novais C, Read A, Alves V, Peixe L. Int J Antimicrob Agents. 2016 Jun;47(6):500-1. doi: 10.1016/j.ijantimicag.2016.03.011
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    Multilevel population genetic analysis of vanA and vanB Enterococcus faecium causing nosocomial outbreaks in 27 countries (1986-2012). Freitas AR, Tedim AP, Francia MV, Jensen LB, Novais C, Peixe L, Sánchez-Valenzuela A, Sundsfjord A, Hegstad K, Werner G, Sadowy E, Hammerum AM, Garcia-Migura L, Willems RJ, Baquero F, Coque TM. J Antimicrob Chemother. 2016 Aug 15. pii: dkw312
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    Relevance of tcrYAZB operon acquisition for Enterococcus survival at high copper concentrations under anaerobic conditions. Mourão J, Rae J, Silveira E, Freitas AR, Coque TM, Peixe L, Antunes P, Novais C. J Antimicrob Chemother. 2016 Feb;71(2):560-3. doi: 10.1093/jac/dkv330
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    Filling the map for antimicrobial resistance in sub-Saharan Africa: ampicillin-resistant Enterococcus from non-clinical sources in Angola. Martins E, Novais C, Freitas AR, Dias AR, Ribeiro TG, Antunes P, Peixe L. J Antimicrob Chemother. 2015 Oct;70(10):2914-6. doi: 10.1093/jac/dkv172
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    The work on which these articles are based has been (co-)funded by an ESCMID Research Grant 2013 to Ana Freitas, Porto, Portugal.
  • Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes. Jensen RH, Hagen F, Astvad KM, Tyron A, Meis JF, Arendrup MC. Clin Microbiol Infect. 2016 Jun;22(6):570.e1-9. doi: 10.1016/j.cmi.2016.04.001
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Rasmus H. Jensen, Copenhagen, Denmark.
  • Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates. Ajdačić V, Senerovic L, Vranić M, Pekmezovic M, Arsic-Arsnijevic V, Veselinovic A, Veselinovic J, Šolaja BA, Nikodinovic-Runic J, Opsenica IM. Bioorg Med Chem. 2016 Mar 15;24(6):1277-91. doi: 10.1016/j.bmc.2016.01.058
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    This work has been (co-)funded by an ESCMID Research Grant 2015 to Jasmina Nikodinovic-Runic, Belgrade, Serbia.
  • HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus. Nicolás-Párraga S, Gandini C, Pimenoff VN, Alemany L, de Sanjosé S, Xavier Bosch F, Bravo IG; RIS HPV TT and HPV VVAP study groups. Cancer Med. 2016 Oct;5(10):2909-2919. doi: 10.1002/cam4.870
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    This work has been (co-)funded by an ESCMID Research Grant 2015 to Ville N. Pimenoff, Barcelona, Spain.
  • Prevention of polymicrobial biofilms composed of Pseudomonas aeruginosa and pathogenic fungi by essential oils from selected Citrus species. Pekmezovic M, Aleksic I, Barac A, Arsic-Arsenijevic V, Vasiljevic B, Nikodinovic-Runic J, Senerovic L. Pathog Dis. 2016 Nov;74(8). pii: ftw102
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    This work has been (co-)funded by an ESCMID Research Grant 2015 to Lidija Senerovic, Belgrade, Serbia.

Highlighted articles 2015

Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations. Jensen RH, Astvad KM, Silva LV, Sanglard D, Jørgensen R, Nielsen KF, Mathiasen EG, Doroudian G, Perlin DS, Arendrup MC. J Antimicrob Chemother. 2015 Sep;70(9):2551-5. doi: 10.1093/jac/dkv140
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This work has been (co-)funded by an ESCMID Research Grant 2013 to Rasmus H. Jensen, Copenhagen, Denmark.

Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation. De Majumdar S, Yu J, Fookes M, McAteer SP, Llobet E, Finn S, Spence S, Monahan A, Kissenpfennig A, Ingram RJ, Bengoechea J, Gally DL, Fanning S, Elborn JS, Schneiders T. PLoS Pathog. 2015 Jan 29;11(1):e1004627. doi: 10.1371/journal.ppat.1004627
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This work has been (co-)funded by an ESCMID Research Grant 2011 to Thamarai Schneiders, Belfast, UK.

Further articles published in 2015

  • The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters. Lo Cigno I, De Andrea M, Borgogna C, Albertini S, Landini MM, Peretti A, Johnson KE, Chandran B, Landolfo S, Gariglio M. J Virol. 2015 Aug;89(15):7506-20. doi: 10.1128/JVI.00013-15
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • Identification of the skin virome in a boy with widespread human papillomavirus-2-positive warts that completely regressed after administration of tetravalent human papillomavirus vaccine. Landini MM, Borgogna C, Peretti A, Doorbar J, Griffin H, Mignone F, Lai A, Urbinati L, Matteelli A, Gariglio M, De Andrea M. Br J Dermatol. 2015 Aug;173(2):597-600. doi: 10.1111/bjd.13707
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • The interferon-inducible DNA-sensor protein IFI16: a key player in the antiviral response. Dell'Oste V, Gatti D, Giorgio AG, Gariglio M, Landolfo S, De Andrea M. New Microbiol. 2015 Jan;38(1):5-20
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Valentina Dell'Oste, Turin, Italy.
  • Polymorphonuclear Cell Functional Impairment in Relapsing Remitting Multiple Sclerosis Patients: Preliminary Data. Allizond V, Scutera S, Rossi S, Musso T, Crocillà C, Cavalla P, Trebini C, Marra ES, Cuffini AM, Banche G. PLoS One. 2015 Jun 29;10(6):e0131557. doi: 10.1371/journal.pone.0131557
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Valentina Dell'Oste, Turin, Italy.
  • The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line. Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM. Infect Immun. 2015 Feb;83(2):812-21. doi: 10.1128/IAI.02713-14
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    This work has been (co-)funded by an ESCMID Research Grant 2014 to Ana Sofia Ferreira, Lisbon, Portugal.
  • In vivo Candida glabrata biofilm development on foreign bodies in a rat subcutaneous model. Kucharíková S, Neirinck B, Sharma N, Vleugels J, Lagrou K, Van Dijck P. J Antimicrob Chemother. 2015 Mar;70(3):846-56. doi: 10.1093/jac/dku447
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Sona Kucharikova, Leuven, Belgium.
  • A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits. Massari S, Nannetti G, Desantis J, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Palù G, Cruciani G, Loregian A, Goracci L, Tabarrini O. J Med Chem. 2015 May 14;58(9):3830-42. doi: 10.1021/acs.jmedchem.5b00012
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Beatrice Mercorelli, Padova, Italy.
  • Increase of widespread A, B1 and D Escherichia coli clones producing a high diversity of CTX-M-types in a Portuguese hospital. Rodrigues C, Machado E, Pires J, Ramos H, Novais Â, Peixe L. Future Microbiol. 2015;10(7):1125-31. doi: 10.2217/fmb.15.38
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    This work has been (co-)funded by an ESCMID Research Grant 2012 to Angela Novais, Porto, Portugal.
  • Multidrug resistant Mycobacterium tuberculosis of the Latin American Mediteranean lineage wrongly identified as Mycobacterium pinnipedii (ST863) causing active tuberculosis in south Brazil. Dalla Costa ER, Vasconcelos SE, Esteves LS, Gomes HM, Gomes LL, Almeida da Silva P, Perdigão J, Portugal I, Viveiros M, McNerney R, Pain A, Clark TG, Rastogi N, Unis G, Rossetti ML, Suffys PN. J Clin Microbiol. 2015 Sep 23. pii: JCM.02012-15
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    This work has been (co-)funded by an ESCMID Research Grant 2015 to Joao Perdigao, Lisbon, Portugal.

Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med. 2014

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A. N Engl J Med. 370(5):421-32 (2014) (free full text)

This work has been (co-)funded by an ESCMID Research Grant 2012 to Agostinho Carvalho, Perugia, Italy.

Further articles published in 2014

  • Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients. Borgogna C, Lanfredini S, Peretti A, De Andrea M, Zavattaro E, Colombo E, Quaglia M, Boldorini R, Miglio U, Doorbar J, Bavinck JN, Quint KD, de Koning MN, Landolfo S, Gariglio M. Mod Pathol. 2014 Aug;27(8):1101-15. doi: 10.1038/modpathol.2013.240
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • α- and β-papillomavirus infection in a young patient with an unclassified primary T-cell immunodeficiency and multiple mucosal and cutaneous lesions. Landini MM, Borgogna C, Peretti A, Colombo E, Zavattaro E, Boldorini R, Miglio U, Doorbar J, Ravanini P, Kumar R, Moratto D, Badolato R, De Andrea M, Gariglio M. J Am Acad Dermatol. 2014 Jul;71(1):108-15.e1. doi: 10.1016/j.jaad.2014.01.859
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • Characterization of skin lesions induced by skin-tropic α- and β-papillomaviruses in a patient with epidermodysplasia verruciformis. Borgogna C, Landini MM, Lanfredini S, Doorbar J, Bouwes Bavinck JN, Quint KD, de Koning MN, Genders RE, Gariglio M. Br J Dermatol. 2014 Dec;171(6):1550-4. doi: 10.1111/bjd.13156
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • Analysis of human β-papillomavirus and Merkel cell polyomavirus infection in skin lesions and eyebrow hair bulbs from a cohort of patients with chronic lymphocytic leukaemia. Peretti A, Borgogna C, Rossi D, De Paoli L, Bawadekar M, Zavattaro E, Boldorini R, De Andrea M, Gaidano G, Gariglio M. Br J Dermatol. 2014 Dec;171(6):1525-8. doi: 10.1111/bjd.13215
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Cinzia Borgogna, Novara, Italy.
  • Innate nuclear sensor IFI16 translocates into the cytoplasm during the early stage of in vitro human cytomegalovirus infection and is entrapped in the egressing virions during the late stage. Dell'Oste V, Gatti D, Gugliesi F, De Andrea M, Bawadekar M, Lo Cigno I, Biolatti M, Vallino M, Marschall M, Gariglio M, Landolfo S. J Virol. 2014 Jun;88(12):6970-82. doi: 10.1128/JVI.00384-14
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Valentina Dell'Oste, Turin, Italy.
  • Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection. Fitzmaurice K, Hurst J, Dring M, et al. Gut. 2014 Jul 4. pii: gutjnl-2013-306287. doi: 10.1136/gutjnl-2013-306287
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    This work has been (co-)funded by an ESCMID Research Grant 2012 to Karen Fitzmaurice, Oxford, UK.
  • Pneumonia in solid organ transplant recipients: a prospective multicenter study. M. Giannella, P. Muñoz, J.M. Alarcón, et al. Transpl Infect Dis 2014: 16: 232–241
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    This work has been (co-)funded by an ESCMID Research Grant 2012 to Maddalena Giannella, Madrid, Spain.
  • Klebsiella variicola Is a Frequent Cause of Bloodstream Infection in the Stockholm Area, and Associated with Higher Mortality Compared to K. pneumoniae. Maatallah M, Vading M, Kabir MH, et al. (2014) PLoS ONE 9(11): e113539. doi: 10.1371/journal.pone.0113539
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    This work has been (co-)funded by an ESCMID Research Grant 2010 to Christian Giske, Stockholm, Sweden.
  • Global Genomic Diversity of Human Papillomavirus 6 Based on 724 Isolates and 190 Complete Genome Sequences. Mateja M. Jelen, Zigui Chen, Bostjan J. Kocjan, et al. J. Virol. July 2014 vol. 88 no. 13 7307-7316
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    This work has been (co-)funded by an ESCMID Research Grant 2014 to Mateja Jelen, Ljubljana, Slovenia.
  • Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei. Rasmus Hare Jensen, Ulrik Stenz Justesen, Annika Rewes, David S. Perlin, and Maiken Cavling Arendrup. Antimicrob Agents Chemother. 2014 Jun; 58(6): 3550–3552 doi:  10.1128/AAC.02367-14
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Rasmus Hare Jansen, Copenhagen, Denmark.
  • The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication. Mercorelli B, Luganini A, Muratore G, Massari S, Terlizzi ME, Tabarrini O, Gribaudo G, Palù G, Loregian A. Antimicrob Agents Chemother. 2014 Nov;58(11):6615-26. doi: 10.1128/AAC.03309-14
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    Optimization of small-molecule inhibitors of influenza virus polymerase: from thiophene-3-carboxamide to polyamido scaffolds. Lepri S, Nannetti G, Muratore G, Cruciani G, Ruzziconi R, Mercorelli B, Palù G, Loregian A, Goracci L. J Med Chem. 2014 May 22;57(10):4337-50. doi: 10.1021/jm500300r
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    Antiviral strategies against influenza virus: towards new therapeutic approaches. Loregian A, Mercorelli B, Nannetti G, Compagnin C, Palù G. Cell Mol Life Sci. 2014 Oct;71(19):3659-83. doi: 10.1007/s00018-014-1615-2
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Beatrice Mercorelli, Padova, Italy.
  • Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone. Carla Rodrigues, Ângela Novais, Elisabete Machado and Luísa Peixe. J. Antimicrob. Chemother. (2014) 69 (1): 274-275. doi: 10.1093/jac/dkt314
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    MALDI-TOF mass spectrometry as a tool for the discrimination of high-risk Escherichia coli clones from phylogenetic groups B2 (ST131) and D (ST69, ST405, ST393). Novais Â, Sousa C, de Dios Caballero J, Fernandez-Olmos A, Lopes J, Ramos H, Coque TM, Cantón R, Peixe L. Eur J Clin Microbiol Infect Dis. 2014 Aug;33(8):1391-9. doi: 10.1007/s10096-014-2071-5
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    This work has been (co-)funded by an ESCMID Research Grant 2012 to Angela Novais, Porto, Portugal.
  • The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon alpha treatment. Tom Pembroke, Adam Christian, Emma Jones, et al. Gut 2014;63:515-524 doi:10.1136/gutjnl-2013-304472
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    This work has been (co-)funded by an ESCMID Research Grant 2012 to Tom Pembroke, Cardiff, UK.
  • First Whole-Genome Sequence of a Clinical Isolate of Multidrug-Resistant Mycobacterium bovis BCG. Renvoisé A, Pang S, Bernard C, Brossier F, Veziris N, Capton E, Jarlier V, Sougakoff W. Genome Announc. 2014 Jul 10;2(4). pii: e00611-14. doi: 10.1128/genomeA.00611-14
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Aurelie Renvoise, Paris, France.
  • USA300 methicillin-resistant Staphylococcus aureus in Zurich, Switzerland between 2001 and 2013. Seidl K, Leimer N, Palheiros Marques M, et al. Int J Med Microbiol. 2014 Nov;304(8):1118-22. doi: 10.1016/j.ijmm.2014.08.005
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    This work has been (co-)funded by an ESCMID Research Grant 2013 to Kati Seidl, Zurich, Switzerland.
  • A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. Sanderson-Smith M, De Oliveira DM, Guglielmini J, et al. J Infect Dis. 2014 Oct 15;210(8):1325-38. doi: 10.1093/infdis/jiu260
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    This work has been (co-)funded by an ESCMID Research Grant 2009 to Pierre R. Smeesters, Gosselies, Belgium.
  • The glucosaminidase domain of Atl - the major Staphylococcus aureus autolysin - has DNA-binding activity. Grilo IR, Ludovice AM, Tomasz A, de Lencastre H, Sobral RG. Microbiology open. 2014 Apr;3(2):247-56. doi: 10.1002/mbo3.165
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    Living bacteria rheology: population growth, aggregation patterns, and collective behavior under different shear flows. Patrício P, Almeida PL, Portela R, Sobral RG, Grilo IR, Cidade T, Leal CR. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):022720
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    This work has been (co-)funded by an ESCMID Research Grant 2011 to Rita Sobral, Oeiras, Portugal.

Last update: 07 November 2016