Improving the Dosage of Old Antibiotics, ESCMID Postgraduate Education Course

19 - 21 November 2015, Warsaw, Poland

  • ESCMID PK/PD of Anti-Infectives Study Group (EPASG)
  • AIDA (EU FP7 funded project)
Course Coordinators
  • Johan Mouton, Rotterdam, Netherlands
  • Ursula Theuretzbacher, Vienna, Austria
Course Objectives

This course presents and summarizes currently available knowledge regarding optimized clinical use of revived old antibiotics such as colistin, fosfomycin, temocillin, pivmecillinam, nitrofurantoin, fusidic acid, minocycline. The aim is to provide participants with an updated insight into clinical PK/PD concepts, improved dosage regimens, combinations, appropriate indications as a
key contribution to preserving the efficacy of these essential drugs in an era of escalating multi-drug resistance.

Course Venue

Hotel Bristol
Krakowskie Przedmiescie 42/44
00325 Warsaw

Target Audience

About 20–30 infectious disease, ICU or haematology specialists from academia (or companies), clinical microbiologists, pharmacologists, pharmacists, who work or want to work in the field of antibacterial therapy.

Contact Person (Scientific Programme)

Johan Mouton
Unit Head Research and Development
Department of Medical Microbiological
Infectious Diseases at Erasmus MC
Postbus 2040
3000 CA Rotterdam

Administrative Secretariat

Dr Ramprasath Venkatachalam
Project Manager
Department of Medical Microbiological
Infectious Diseases at Erasmus MC
Postbus 2040
3000 CA Rotterdam

Phone +31 107 033 510
Fax +31 107 033 875

Course Programme

Presentations are availabe in the ESCMID Online Lecture Library.

Thursday, 19 November 2015

13:30 Registration & lunch
14:30 Welcome and introduction. Johan Mouton
15:00 Why do we need to revive old antibiotics? Ursula Theuretzbacher
15:30 Basics of optimal dosing (interactive). Johan Mouton
16:30 Break
17:00 Dosing in special patient populations (interactive).
           William Hope & Lena Friberg
19:30 Dinner

Friday, 20 November 2015

09:00 Emergence of resistance in individual patients. Yehuda Carmeli
09:30 Safety concerns and their relation to dosing. Karen Bowker
10:00 Reviving old antibiotics: the AIDA experience – preserving old                                     antibiotics for the future. Ursula Theuretzbacher
10:30 Break
11:00 Integration of dosing into stewardship programmes (interactive).
           Mical Paul
11:45 Interpretation of clinical trial results (clinical case studies, interactive).                      Leonard Leibovici & Mical Paul
13:00 Lunch
14:00 What do we know about nitrofurantoin? Anouk Muller
14:30 What do we know about fosfomycin? Angela Huttner
15:00 What do we know about minocyclin? Alasdair MacGowan
15:30 Break
16:00 How to optimize the use of oral antibiotics: nitrofurantoin, fosfomycin-trometamol, mecillinam, rifampicin, minocycline and other antibiotics (clinical case studies, interactive). Stephan Harbarth, Anouk Muller, William Hope, Niels Frimodt-Möller, Angela Hutter, Alasdair MacGowan & Maciek Godycki-Cwirko
17:30 Quiz
19:30 Dinner

Saturday, 21 November 2015

09:00 The clinical use of colistin: past, present, future. Mical Paul
09:40 How to set breakpoints of old antibiotics: the EUCAST approach                                (interactive). Johan Mouton & Alasdair MacGowan
10:20 Therapeutic drug monitoring of old antibiotics. William Couet
11:00 Break
11:30 Tools to support dosing decisions (case presentation, interactive).
           William Hope
12:30 How to optimize the use of i.v. antibiotics: Colistin, ß-lactams and other old antibiotics (clinical case studies, interactive). William Couet, Johan Mouton & Alasdair MacGowan
13:30 Closure
13:35 Lunch

Faculty Members
  • Karen Bowker, Bristol, United Kingdom
  • Yehuda Carmeli, Tel Aviv, Israel
  • William Couet, Poitiers, France
  • Lena Friberg, Uppsala, Sweden
  • Niels Frimodt-Möller, Copenhagen, Denmark
  • Maciek Godycki-Cwirko, Lodz, Poland
  • Stephan Harbarth, Geneva, Switzerland
  • William Hope, Liverpool, United Kingdom
  • Angela Huttner, Geneva, Switzerland
  • Leonard Leibovici, Petah-Tiqva, Israel
  • Alasdair MacGowan, Bristol, United Kingdom
  • Johan Mouton, Rotterdam, Netherlands
  • Anouk Muller, The Hague, Netherlands
  • Mical Paul, Haifa, Israel
  • Ursula Theuretzbacher, Vienna, Austria