Significance of Experimental Models for Studying Bacterial Meningitis and Sepsis, ESCMID Postgraduate Education Course

14 - 17 May 2012, Siena, Italy

  • ESCMID Meningitis Study Group (EMESG)
  • Università degli Studi di Siena
Course Coordinators
  • Marco Oggioni, Siena, Italy
  • Stephen Leib, Berne, Switzerland
Course Objectives

This course aims to provide a critical insight in to pros and cons of work on experimental models of invasive infection. It will target the whole process of experimental setup from planning to execution – from animal facility to statistics. The course offers theoretical and practical sessions and includes time for a 10 –15 minute presentation from each participant on her/his own work.


Course Venue

Certosa di Pontignano
Siena, Italy


Target Audience

20 graduate and postgraduate students, experienced in animal work involving the study of experimental invasive infections

Contact Person

Marco Oggioni, Siena, Italy

Administrative Secretariat

Marina Piccinin
LAMMB, Policlinico Le Scotte
lotto 5 (piano 1)
53100 Siena, Italy

Phone +39 0577 233 101/299
FAX +39 0577 233 334

Course Programme


Presentations are availabe in the ESCMID Online Lecture Library.


Monday, 14 May 2012
19.30 Welcome and dinner

Tuesday, 15 May 2012
09.00 – 11.00 Lectures
11.30 – 12.30 Seminars by students
15.00 – 17.00 Seminar and round table
17.30 – 18.30 Seminars by students

Wednesday, 16 May 2012
09.00 – 11.00 Lectures
11.30 – 12.30 Seminars by students
15.00 – 18.00 Seminar and round table
18.30 – 19.30 Seminars by students

Thursday, 17 May 2012
09.30 – 12.00 Lectures
12.00 – 13.00 Summing up



  • Making sense of data-rich biological methods
  • Use of laboratory animals in research: a veterinary perspective
  • Switch from planktonic to sessile life, a major event in pneumococcal pathogenesis of meningitis: Translational aspects
  • A novel experimental model of Neisseria meningitidis meningitis in mice with meaningful immunological and histopathological outcome measurements
  • Paediatric pneumococcal meningitis: Modelling brain damage and neurofunctional sequelae in the infant rat
  • Using adult mice to study pneumococcal meningitis: pros and cons
  • A long-term stable model of asymptomatic nasopharyngeal carriage using outbred naive mice to study the immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease
  • Experimental murine pneumococcal meningitis models to study new classes of antibiotics
  • What use is the human genome for understanding the mouse?
  • Outcome measures for pneumococcal meningitis in the adult rat
  • The significance of the rat model of cerebral aspergillosis
Course Faculty
  • Peter Andrew, Leicester, UK
  • Elisa Borghi, Milan, IT
  • Paul Denny, Harwell, UK
  • Aras Kadioglu, Liverpool, UK
  • Matthias Klein, Munich, DE
  • Uwe Koedel, Munich, DE
  • Stephen Leib, Berne, CH
  • Marco Oggioni, Siena, IT
  • Christian Ostergaard, Copenhagen, DK
  • Susanna Ricci, Siena, IT
  • Eckart Thein, Munich, DE
  • Marceline van Furth, Amsterdam, NL
  • Matthias Wittwer, Spiez, CH
  • Stefan Zimmerli, Berne, CH