Bringing PK and PD in Fungal Infections into the Clinic, ESCMID Postgraduate Education Course

4 - 6 July 2014, Nijmegen, The Netherlands

  • ESCMID PK/PD of Anti-Infectives Study Group (EPASG)
  • ESCMID Fungal Infection Study Group (EFISG)
  • Radboud University Medical Center, Nijmegen, The Netherlands
  • National and Kapodistrian University of Athens, Athens, Greece
  • Center for Anti-Infective Agents, Vienna, Austria
  • Julius-Maximilians-Universität, Würzburg, Germany
Course Coordinators
  • Roger Brüggemann, Nijmegen, The Netherlands
  • Joseph Meletiadis, Athens, Greece
  • Ursula Theuretzbacher, Vienna, Austria
  • Andrew Ullmann, Würzburg, Germany
Course Objectives
  • To learn PK/PD principles of antifungal therapy
  • To learn the pharmacokinetic differences among different patient populations
  • To understand resistance mechanisms of fungi and their impact on antifungal treatment
  • To learn how to use in vitro susceptibility data and to understand what breakpoints mean
  • To explore the utility of therapeutic drug monitoring, the principles of dose adjustment and how to optimise the therapy
  • To understand the different clinical approaches of antifungal therapy and prophylaxis
  • To learn how to apply antifungal stewardship in your centre

Course Venue

Hampshire Landgoedhotel – Holthurnsche Hof
Zevenheuvelenweg 48a
6571 CK – Berg en Dal, The Netherlands

Phone +31 (0)24 684 17 44

Target Audience

30 – 40 clinical microbiologists, pharmacologists and infectious disease, ICU or haematology specialists from academia (or companies) who work or want to
work in the field of antifungal drugs and fungal infections. Participants should have a basic understanding of pharmacokinetics and pharmacodynamics.

Contact Person

Joseph Meletiadis, PhD
Assistant Professor of Microbiology
Medical School, National and Kapodistrian
University of Athens
Clinical Microbiology Laboratory
“Attikon” University General Hospital
Rimini 1 st, Haidari 12462
Athens, Greece

Phone +30 210 583 19 09
Fax +30 210 532 64 21

Administrative Secretariat

UMC St Radboud
Department of Pharmacy
Geert Grooteplein 10
6525 Nijmegen, The Netherlands

Phone +31 243 616 405
Fax +31 243 668 755

Course Programme

Presentations are availabe in the ESCMID Online Lecture Library.

Friday, 4 July 2014

18:00 Registration

PK/PD: general principles
18:15 Welcome and introduction. R. Brüggemann
18:30 General principles of PK/PD. U. Theuretzbacher
20:00 Welcome reception & dinner

Saturday, 5 July 2014

Pharmacokinetics in fungal infections
09:00 PK in neonates and children. E. Jacqz-Aigrain
09:40 PK in special patient population, e.g. frail, obese, ICU, CF and cancer                       patients. R. Brüggemann
10:20 Coffee break
10:50 Multi-organ failure in antifungal treatment: renal replacement                                     treatments – are all alike? J. Meletiadis
11:30 Interactive discussion: PK case presentation. J. Mouton & O. Marchetti
12:30 Lunch

Pharmacodynamics in fungal infections
14:00 What are the implications of resistance in our patients’ population?
           P. Verweij
14:45 What do susceptibility results and breakpoints mean for us?
           M. Sanguinetti
15:30 Coffee break
16:00 Biofilms: how to handle them? C. Imbert
16:45 Interactive discussion: PD case presentation. J. Mouton & O. Marchetti
17:45 Concluding remarks of the second day

Sunday, 6 July 2014

Bringing PK/PD into the clinic
09:30 Finding the right dose. W. Hope
10:00 Meet the experts: antifungal therapy (case studies).
           J. Maertens & R. Brüggemann
11:00 Coffee break
11:15 Meet the experts: antifungal prophylaxis (case studies).
           W. Heinz & L. Pagano
12:15 Antifungal stewardship. A. Ullmann
12:45 Concluding remarks of the last day & closure of the workshop

Invited Faculty Members
  • Roger Brüggemann, Nijmegen, The Netherlands
  • Werner Heinz, Würzburg, Germany
  • William Hope, Liverpool, United Kingdom
  • Christine Imbert, Poitiers, France
  • Evelyne Jacqz-Aigrain, Paris, France
  • Johan Maertens, Leuven, Belgium
  • Oscar Marchetti, Lausanne, Switzerland
  • Joseph Meletiadis, Athens, Greece
  • Johan Mouton, Nijmegen, The Netherlands
  • Livio Pagano, Rome, Italy
  • Maurizio Sanguinetti, Rome, Italy
  • Ursula Theuretzbacher, Vienna, Austria
  • Andrew Ullmann, Würzburg, Germany
  • Paul Verweij, Nijmegen, The Netherlands