We would like to highlight two publications in 2015 on excellent projects that were made possible by ESCMID research grants. Rasmus Hare Jansen, Copenhagen, Denmark, co-funded by an ESCMID Research Grant in 2013, published a paper on the examination of mutations in Candida albicans and its adaptation to antifungal exposure. The authors followed the stepwise emergence of multidrug-resistance by analysing Candida in a patient over time and scrutinized the observed changes by susceptibility testing, MLST, gene expression analysis and virulence determination in an insect model.
A second publication worth highlighting was project co-funded by an ESCMID Research Grant 2011 to Thamarai Schneiders, Belfast, United Kingdom. The author describes how microbial immune evasive strategies contribute to the development and persistence of antimicrobial resistance. She showed that RamA plays a role in both protection against antibiotic challenge and also against the innate host immune response thus resulting in Klebsiella that are less susceptible to antibiotics and simultaneously more virulent. As of July, we are looking forward to receiving project submissions focusing on fungal, viral and parasitic infections and diseases for the 2017 research grants.