Carbapenemase-producing Gram-negative Microorganisms: Detection, Epidemiology and Therapeutic Challanges, ESCMID Postgraduate Education Course

1 - 2 December 2011, Athens, Greece


Hellenic Society for Chemotherapy and the Hellenic National School of Public Health

Course Materials

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Thursday, 1 December 2011


I. Classification and Epidemiology of Carbapenemases

Introduction to beta-lactamases. Irene Galani (GR)


Classification and hydrolytic activity of carbapenemases. Vivi Miriagou (GR)


Genetic structures at the origin of acquisition of the carbapenemase genes. Laurent Poirel (FR)

II. Laboratory Issues
11:30–12:00        When to suspect the presence of carbapenemases. Methods for phenotypic detection. Athanassios Tsakris (GR)
12:00–12:30The rationale behind the EUCAST susceptibility breakpoints and new expert rules for carbapenems. Rafael Canton (ES)
How to effectively report laboratory findings to clinicians (Breakpoints and Interpretation). Alkis Vatopoulos (GR)
III. Carbapenemase-Producing Bacteria: International Experience
14:00–14:30   The European experience on carbapenemases. Gian Maria Rossolini (IT)
The Israeli and USA experience on carbapenemases. Yehuda Carmeli (IL)
15:00–15:30 The Greek experience on carbapenemases. Maria Souli (GR)
Friday, 2 December 2011


IV. Therapeutic Challenges

Carbapenemase-producing Enterobacteriaceae with low-level resistance to carbapenems: Do we have more treatment options? George L. Daikos (GR)

Colistin in the treatment of infections by carbapenemase-producing bacteria. Diamantis Plachouras (GR)
Tigecycline in the treatment of infections by carbapenemase-producing bacteria. Garyphallia Poulakou (GR)
10:30–11:00Fosfomycin in the treatment of infections by carbapenemase-producing bacteria. Helen Giamarellou (GR)
V. Laboratory Rounds and Case Presentations
Case Presentations: From the agar plate to the patient
Anastasia Antoniadou (GR) & George L. Daikos (GR)
VI. Prevention and Control
14:30–15:00Infection control issues. Anastasia Antoniadou (GR)
Focusing on antibiotic stewardship. Helen Giamarellou (GR)


Course Faculty
  • Anastasia Antoniadou, Athens, GR
  • Rafael Canton, Madrid, ES
  • Yehuda Carmeli, Tel Aviv, IL
  • George L. Daikos, Athens, GR
  • Irene Galani, Athens, GR
  • Helen Giamarellou, Athens, GR
  • Vivi Miriagou, Athens, GR
  • Diamantis Plachouras, Athens, GR
  • Laurent Poirel, Paris, FR
  • Garyphallia Poulakou, Athens, GR
  • Gian Maria Rossolini, Siena, IT
  • Maria Souli, Athens, GR
  • Athanassios Tsakris, Athens, GR
  • Alkis Vatopoulos, Athens, GR
Contact Person

Helen Giamarellou

Phone +30 2106867946
Fax +30 2106867377


Administartive Secretariat

Imagine Congress and Travel
Mrs Vanna Antonopoulou & Mrs Christina Luthi
Kolokotroni str 9
10562 Athens, Greece

Tel +30 210 3252520
Fax +30210 3252530

Course Objectives

The course participants will be able to:

  • Review the current knowledge on epidemiology of carbapenemase-producers.
  • Recognise or suspect Carbapenemase-producing microorganisms at the laboratory level and proceed to further identification.
  • Understand and support the infection control issues which will prevent the spread of carbapenemase-producing microorganisms in their institutions.
  • Discuss treatment options against carbapenemase-producing pathogens as well as the appropriate antibiotic stewardship. 
Target Audience

60 - 100 infectious disease physicians and clinical microbiologists