Research & Projects

ESCMID Panorama

ESCMID PK/PD of Anti-Infectives Study Group - EPASG

News & Activities

04 August 2015
EPASG activities on reviving old antibiotics to fight antimicrobial resistance

EPASG is organizing a course entitled Improving the Dosage of Old Antibiotics from 19-21 November in Warsaw, Poland. The group was also in charge of the successful 2014 conference Reviving Old Antibiotics. A list of the publications EPASG members published on that conference can be found on the conference website including a lead article and editor’s choice in the Journal of Antimicrobial Chemotherapy as well as links to articles in the September issue of CMI, which will be dedicated to the conference.

In addition, the EPASG-supported pipeline corner held for the first time at this year’s ECCMID received coverage in a feature article by Ursula Theuretzbacher in Genetic Engineering News last week.

EPASG members invited to EMA workshop on PK/PD in the development of antibacterial medicinal products

The European Medicines Agency (EMA) invited EPASG members (Ursula Theuretzbacher, Alasdair MacGowan, Johan Mouton, Elisabet Nielsen) to a workshop discussing pharmacokinetics and pharmacodynamics in the development of antibacterial medicinal products. The presentations and discussions will support the drafting of a regulatory guideline for developers on PK/PD of antibacterial agents, as proposed by a concept paper (downloadable here).

Comments are welcomed by 23 October 2015 (email to ).

This comprehensive resource on old antibiotics provides information on

  • Current knowledge of old revived antibiotics regarding PK/PD, dosing, emergence of resistance
  • Knowledge gaps and current research activities
  • Regulatory aspects and inventory of outdated dosing regimens, analysis of Summary of Product Characteristics (SPCs)
  • Regularly updated new knowledge, especially from the FP7 AIDA project on "Old antibiotics for the future"

Future projects

So far two major projects are planned for 2013 and hopefully suggestions for more activities will be discussed during our business meeting at ECCMID in Berlin (see below for details).

  • New Life for Old Antibiotics: This project will create the first inventory of dosing regimens of old antibiotics in European countries that need an update of their dosing schedules and indication list to preserve their efficacy.
  • ESCMID and EPASG will co-organise the first Conference “Re-development of Old Antibiotics” in October 2014 in Vienna, Austria. The first announcement will be available at ECCMID in Berlin.

EU Projects

  • Many of the founding members, along with other active Study Group members are collaborating in the FP7 funded Project AIDA: “Preserving old antibiotics for the future: assessment of clinical efficacy by a pharmacokinetic/pharmacodynamic approach to optimize effectiveness and reduce resistance for off-patent antibiotics”. As Project AIDA progresses, we will post additional background information and project results to our project website (www.aida-project.eu).
  • A similar team of active Study Group members under the leadership of J. Mouton prepared a proposal in response to the FP7-HEALTH-2013-INNOVATION-1 call “Stratified approaches to antibacterial and/or antifungal treatment.”

FP7-HEALTH.2011.2.3.1-1 Investigator-driven clinical trials of off-patent antibiotics.
Topic:  Defining optimal treatment regimens (including drug choice, combinations, dosing, duration of therapy, PK/PD, individualisation) of off-patent antimicrobial agents for therapy of difficult-to-treat infections caused by multidrug resistant bacterial pathogens in terms of maximising clinical benefit and minimizing selection of resistance.

The application for this two-stage grant has been accepted by the European Commission.

We will proceed with our planning for 3 randomised clinical trials, in vitro, animal studies, as well as dissemination and educational activities

Project leader:

First PK/PD Symposium in Vienna, AT

  • Symposium after the ECCMID 2010 in Vienna: Special PK/PD topics in collaboration with ISAP, 13 April 2010, 14.00-17.30
    Programme

Download the latest Annual Report.

A new knowledge resource from EPASG!