ESCMID Publications

ESCMID Panorama

Although the polymyxins became available in the 1950s, interest in them as salvage therapy for multidrug-resistant and extensively drug-resistant gram-negative infections recently reemerged. However, the lack of standard drug development procedures in the 1950s resulted in significant confusion surrounding their current use.

To address this confusion and provide practitioners with a guide to the optimal clinical use of the polymyxin antibiotics, a diverse, international panel of 18 experts convened over the past 24 months to reach a consensus on therapeutic recommendations.

At the public consultation phase, ESCMID and EUCAST members provided many helpful comments, and ESCMID finally endorsed the consensus document, which provides the first guidance on appropriate investigation and treatment strategies in this patient population, targeting all stakeholders involved in the clinical use of the polymyxin antibiotics, colistin (polymyxin E) and polymyxin B, for the treatment of bacterial infections in adults.


Link to publication

11 September 2017

ESCMID endorses the ERS guidelines for the management of adult bronchiectasis

The guideline is the first international guideline discussing the management of adult patients with clinically significant bronchiectasis. Specifically the document aims to provide guidance on the appropriate investigation and treatment strategies in this patient population, targeting all stakeholders involved in bronchiectasis care.

Through the concerted effort of a multidisciplinary group of clinicians under the lead of James D. Chalmers, nine key clinical questions were generated. After conducting a systematic review of the evidence for each question, the quality of evidence was evaluated and the level of recommendation defined. The resulting full text can be accessed through the following page.

Full reference: European Respiratory Society guidelines for the management of adult bronchiectasis. Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Cantón R, Torres A, Dimakou K, De Soyza A, Hill AT, Haworth CS, Vendrell M, Ringshausen FC, Subotic D, Wilson R, Vilaró J, Stallberg B, Welte T, Rohde G, Blasi F, Elborn S, Almagro M, Timothy A, Ruddy T, Tonia T, Rigau D, Chalmers JD. Eur Respir J. 2017 Sep 9;50(3). pii: 1700629. doi: 10.1183/13993003.00629-2017. Print 2017 Sep.  

15 March 2017

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2016

Crit Care Med. 2017 Mar;45(3):486-552

Intensive Care Med. 2017 Mar;43(3):304-377

ESCMID endorses this guideline.

This guideline came together by the concerted effort of 55 international experts, divided into 5 groups. Each group addressed one of the following topics: hemodynamics, infection, adjunctive therapies, metabolism, and ventilation. The resulting document contains 93 statements on early management and resuscitation of patients with sepsis or septic shock, 32 strong recommendations, 39 weak recommendations and 18 best-practice statements.

Of note, in this version, information on the management of pediatric SSC patients was omitted. This matter will be discussed in a separate publication by the SCCM and the ESICM.

Written by the HIV in Europe initiative that is directed by an independent group of experts which has come together to work for optimal testing and earlier care for HIV in Europe. ESCMID endorses this guidance.

The objectives of the guidance are to:

  • Encourage and support the inclusion of indicator condition-guided HIV testing in national HIV testing strategies, taking into account the local HIV prevalence, ongoing testing programmes and the local healthcare setting;
  • Recommend approaches and practical tools for education and training of healthcare professionals on overcoming barriers to recommending an HIV test.

[Picture © HIV in Europe: HIV Indicator Conditions: Guidance for Implementing HIV Testing in Adults in Health Care Settings]


Full text

HIV in Europe initiative website

Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis

Gilbert Habib (Chairperson); Bruno Hoen; Pilar Tornos; Franck Thuny; Bernard Prendergast; Isidre Vilacosta; Philippe Moreillon; Manuel de Jesus Antunes; Ulf Thilen; John Lekakis; Maria Lengyel; Ludwig Muller; Christoph K. Naber; Petros Nihoyannopoulos; Anton Moritz; Jose Luis Zamorano, EHJ 2009;30:2369-2413


Short statement of the first European consensus conference on the treatement of chronic hepatitis B and C in HIV Co-infected patients

A. Alberti et al., J Hepatol 2005 42: 615-624


Crit Care Med. 2013 Feb;41(2):580-637.

ESCMID endorses this guidance.

Strong agreement existed among a large cohort of international experts regarding many level 1 recommendations for the best care of patients with severe sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for this important group of critically ill patients.

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008

Dellinger RP, Mitchell ML, Carlet JM et al., Crit Care Med 2008 36: 296-327


Last update: 23 August 2016

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Detailed guidance is provided in the ESCMID Operating Procedures for Medical Guidelines.

EOPs for Medical Guidelines