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1. P1666

   Outer mebrane protein targeting antibiotics (OMPTAs): a novel class with potent in vitro and in vivo activity against E. coli-harbouring mcr-1 and/or mcr-3 genes

   Glenn Dale, Allschwil, Switzerland

   G. Dale, J. Teague, C. Vingsbo Lundberg, A. Luther, F. Bernardini, D. Obrecht

   23 April 2018

   Session: Membrane-active antibiotics and peptides: in vitro and in vivo activity

   Relevance:

    

   100%

    

   

   Event: ECCMID 2018
   Madrid, Spain
   Abstract publication

   New Antibacterial Agents & Stewardship

2. P1665

   Outer membrane protein targeting antibiotics (OMPTAs): in vivo characterization of a novel class of compounds with respect to pharmacokinetics, efficacy and renal toxicity

   Glenn Dale, Allschwil, Switzerland

   G. Dale, A. Luther, J. Teague, D. Markovic, F. Bernardini, D. Obrecht

   23 April 2018

   Session: Membrane-active antibiotics and peptides: in vitro and in vivo activity

   Relevance:

    

   100%

    

   

   Event: ECCMID 2018
   Madrid, Spain
   Abstract publication

   New Antibacterial Agents & Stewardship

3. P1311

   Pharmacokinetic of murepavadin (POL7080) and amikacin in a drug-drug interaction phase 1 study in healthy subjects

   Glenn Dale, Allschwil, Switzerland

   Michael Leidig, Frank Schaumann, Laura Beni, Glenn Dale, Achim Wach, Christian Zwingelstein

   24 April 2017

   Session: Murepavadin

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship

4. P1308

   Pharmacokinetic and efficacy analysis of murepavadin (POL7080) co-administered with standard-of-care (SoC) in a phase II study in patients with ventilator-associated pneumonia (VAP) due to suspected or documented Pseudomonas aeruginosa infection

   Glenn Dale, Allschwil, Switzerland

   Apostolos Armaganidis, F Frantzeskaki, C Diakaki, Spyros Zakynthinos, E Ischaki, Konstantinos Mandragos, C Katsenos, M Paraschos, E.j. Giamarellos-Bourboulis, A Pistiki, P Ramirez, Maria Victoria De la Torre-Prados, A Rodriguez, Kay Sommerville, Achim Wach, Christian Zwingelstein, Laura Beni, Leon Hooftman, Glenn Dale, Antoni Torres

   24 April 2017

   Session: Murepavadin

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship

5. P1307

   Population pharmacokinetics modelling of murepavadin (POL7080) and simulation of target attainment in a population with ventilator associated pneumonia due to infection with Pseudomonas aeruginosa

   Glenn Dale, Allschwil, Switzerland

   Matthias Machacek, L Renaud, Achim Wach, Christian Zwingelstein, Laura Beni, Glenn Dale

   24 April 2017

   Session: Murepavadin

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship

6. P1309

   Catabolism and excretion of the anti-pseudomonal antibiotic Murepavadin (POL7080) in humans

   Glenn Dale, Allschwil, Switzerland

   Achim Wach, J Sennhauser, P Kern, Peter Ehmer, Garry Douglas, Laura Beni, Christian Zwingelstein, Glenn Dale

   24 April 2017

   Session: Murepavadin

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship

7. P1310

   In-vitro drug transporter interaction studies with the outer membrane protein targeting anti-pseudomonal antibiotic murepavadin (POL7080)

   Glenn Dale, Allschwil, Switzerland

   Garry Douglas, Anna Klukovits, Erika Nagy, Laura Beni, Christian Zwingelstein, Glenn Dale, Achim Wach

   24 April 2017

   Session: Murepavadin

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship

8. P1367

   POL7001 is highly efficacious in the murine neutropenic lung infection model

   Glenn Dale, Allschwil, Switzerland

   Glenn Dale, Joanne Teague, Pia Thommes, Peter Warn, Jon Hansen, Carina Vingsbo Lundberg, Francesca Bernardini, Daniel Obrecht

   24 April 2017

   Session: New discoveries against Gram-negatives

   Relevance:

    

   100%

    

   

   Event: ECCMID 2017
   Vienna, Austria
   Abstract publication

   New Antibacterial Agents & Stewardship