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5 September 2017

Dear colleagues,

WHO is conducting an online public consultation on monitoring and evaluation (M&E) of the Global Action Plan on AMR. This consultation is open until 17:00 CET 30 September 2017. Access the consultation here.

The Emerging Infections Task Force (EITaF) has published a new contribution about the emerging arbovirus, Oropouche virus, in Central and South America on its webpage. The virus is transmitted by the midge Culicoides paraensis and causes symptoms of fever, joint pain, and headache. Infection may occasionally lead to meningitis or meningoencephalitis. Due to similar symptomatology, Oropouche virus infection can be confused with dengue fever.


Vaccine conference starts this week in Dubrovnik

The 4th ESCMID Conference on Vaccines takes place from 8 – 10 September 2017 in Dubrovnik, Croatia. The European section of the World Health Organization (WHO) and the European Centre for Disease Prevention and Control (ECDC) helped develop a scientific programme for the conference, where about 40 internationally renowned experts present and discuss the latest evidence. Highlights include presentations on the progress that has been made in the management of viral diseases, including Zika or Ebola viruses, which have caused recent difficult-to-contain outbreaks. Experts will also review the current status of some new vaccines of utmost importance and discuss new vaccines as well as efforts to eradicate older diseases including polio.

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AMR/ESCMID AMR conference from 6 – 8 Sept in Boston

Antimicrobial drug resistance (AMR) is an urgent global health problem. New antimicrobial drug development is increasingly viewed as a priority by national and international bodies. There are relatively few agents in developmental pipelines and a paucity of identified microbiological targets that can be exploited for drug development. Co-sponsored by the American Society for Microbiology (ASM) and ESCMID, this multidisciplinary meeting will address the challenges, opportunities and current requirements for antimicrobial drug development for AMR.

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CMI highlight: prophages provide insight into Group B Streptococcus

Researchers in France characterized prophage sequences in 14 isolates, representative of the major lineages, from a collection of 275 human group B Streptococcus isolates. PCR-based detection of prophages revealed the presence of at least one prophage in 72.4% of the 275 isolates and a significant association between neonatal infecting isolates and prophages C, and between adult infecting isolates and prophages A. The results suggest that prophages (possibly animal-associated) have conditioned bacterial adaptation and ability to cause infections in neonates and adults, and support a role of lysogeny with the emergence of GBS as a pathogen in human, the researchers concluded.

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ESGAP antimicrobial stewardship course in Istanbul 5 – 6 October

ESCMID’s study group for antimicrobial stewardship, ESGAP, together with the Turkish Society of Clinical Microbiology and Infectious Diseases, KLIMIK, organizes a postgraduate course on antimicrobial policies. Intersectoral residents and specialists interested in antimicrobial stewardship will get an overview of antimicrobial resistance and stewardship strategies. The registration deadline is 8 September 2017.

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Workshop on ID/CM research and article writing 20 – 21 October in Shanghai

Together with the Shanghai Pulmonary Hospital at the Tongji University School of Medicine, the Shanghai Medical Association and the Youth Committee of Chinese Association of Chest Physicians, ESCMID and publisher Elsevier are organizing a workshop on clinical research and article writing in the fields of infectious diseases and clinical microbiology. The workshop will take place in Shanghai, China on 20 – 21 October.

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ESGMD publication: microbial metagenomics mock scenario-based sample simulation

Despite the increase in software solutions for metagenomics, integration of metagenomics in clinical care, which requires method standardization and validation, is lacking. Motro and Moran-Gilad developed a novel computer module, microbial metagenomics mock scenario-based sample simulation (M3S3). The module was tested by generating virtual shotgun metagenomic samples for ten challenging infectious disease scenarios. For all scenarios, the 80 generated samples showed sequence compositions as predicted from user input. Spiked pathogen sequences were identified with most of the replicates and exhibited acceptable abundance, with slight differences between software tools. The authors conclude that the M3S3 tool can support the development and validation of standardized metagenomics applications in diagnostic workflows of clinical microbiology laboratories.

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