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5 November 2019

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,
ESCMID Executive Office.


New deadline for submission of proposals for ESCMID guidelines projects

Due to several requests received from ESCMID members, the deadline of the first ESCMID call for clinical practice guidelines 2019 has been postponed until Friday, November 15th.

The objective of this call is to invite interested parties to propose to undertake the development of full clinical practice guidelines (following ESCMID guidance manual rules) in one of the priority topics, as listed above. The selected topics are:

1) Antimicrobial stewardship;

2) Diagnosis and management of influenza;

3) Surgical prophylaxis and infection control means, in patients colonised by MDR pathogens before surgery;

4) Diagnostic and treatment of non-hospitalized Community Acquired Pneumonia.

For more information, please visit our website

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Call for 50 ESCMID funded Observerships for Young Scientist Members – Less than 48 hours to go

The call for 50 ESCMID funded Observerships is only open until 7. November 12:00 CET, so last chance to apply during this call. We hope that all ESCMID Young Scientist Members take this opportunity to apply for one of the 50 observerships by using the link below. There you will also find more information about the full eligibility criteria and instructions on how to start the application process. The call is open only for applicants below 35 years or below 40 years and still in training.

In case of questions, please contact: observership@escmid.org

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“Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens” by Mina et al., Science (2019)

In a recent paper published in Science, Prof. Michael J. Mina and colleagues reported that measles virus infection caused partial elimination of the antibody repertoire in unvaccinated children; similar results were obtained in an experimental setting with rhesus macaques. In contrast, the loss of antibody was not observed in infants vaccinated against measles, mumps, and rubella. These findings give insights into the molecular mechanisms that could explain the association of measles with increased morbidity and mortality years after infection. Moreover, they provide strong additional evidence for the need of vaccination against measles.

Prof. Mina recently gave a talk about the long-lasting effects of measles at the 5th ESCMID Conference on Vaccines. He introduces his research interests in this video available on the ESCMID YouTube channel. As for all ESCMID educational activities, his presentation is available on the ESCMID eLibrary.

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New TAE Steering Committee (SC) Members

The elections for the TAE SC Members are closed now and the Trainee Association of ESCMID (TAE) welcomes four new members onto its Steering Committee. The new members on the TAE Steering Committee are Anja Šterbenc from Ljubljana (Slovenia), Ivana Antal from Zagreb (Croatia), Maria Joao Lopes from Amadora (Portugal) and Katharina Last from Homburg (Germany). We look forward to officially welcoming them to their new roles within the TAE Steering Committee

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GARDP websymposium: Converting Gram-positive-only compounds into broad-spectrum antibiotics

Don’t miss the next GARDP Websymposium this Thursday, 7 November, where Paul Hergenrother, Department of Chemistry and the Institute for Genomic Biology University of Illinois, US, will present on the topic ‘Converting Gram-positive-only compounds into broad-spectrum antibiotics’.

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Join the GCP Training in Belgrade, Serbia

COMBACTE (Combatting Antibiotic Resistance in Europe) is welcoming clinical and laboratory investigators from Serbia, Slovenia, Croatia, Bosnia and Bulgaria to a Good Clinical Practice training in Belgrade, Serbia on 19-20 November. The training – given in collaboration with the European Forum for Good Clinical Practice (EFGCP) – offers practical guidance in optimizing the challenging recruitment of patients to support the performance of investigators in clinical trials. Participation is at no cost and attendees will be trained by experts with vast experience in clinical trials and GCP guidelines. Upon successfully passing the exam delegates will receive a GCP Certificate.

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CMI Highlight: Using routine blood parameters to anticipate clinical outcomes in invasive aspergillosis

L. Pang et al, investigated if routine blood counts, creatinine and C-reactive protein (CRP), in addition to the galactomannan index (GMI), might be useful in anticipating clinical outcomes during invasive aspergillosis (IA).

Post-hoc secondary analysis of two multicenter randomized trials was performed. The Global Comparative Aspergillosis Study (GCA, N=123) and the Combination Antifungal Study (CAS, N=251) constituted the discovery and validation cohorts respectively. The outcome measures were response to treatment and survival to 12 weeks. Interval platelet, galactomannan index (GMI) and C-reactive protein (CRP) levels prior and during anti-fungal treatment were analyzed using logistic regression, Kaplan-Meier survival and ROC analyses.

The authors concluded that higher serial platelets were associated with overall survival while galactomannan index trends were linked to invasive aspergillosis treatment response. Routine and simple laboratory indices may aid follow-up of response in invasive aspergillosis patients.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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