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4 June 2019

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,

ESCMID Executive Office.


ECCMID TV – Catch up on the ECCMID that was!

Interviews and insights from Keynote speakers, Programme committee members and ECCMID participants are available to watch on ECCMID TV.

Find out more about the exciting developments from this year, and some sneak peaks at what is to come in 2020!

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Invitation to submit a specific advanced module for the European training programme leading to EUCIC’s Infection Prevention and Control Certificate

EUCIC is opening the selection process for a new excellence center to be included in the European training programme resulting in the EUCIC’s Infection Prevention and Control Certificate. The center should organize the advanced module between May and October 2020The Module will cover the topic of Area 9 – Surveillance.You can read more online at the link below.

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CMI Highlight: A prospective prediction tool for understanding Crimean–Congo haemorrhagic fever dynamics in Turkey

. Ak et al. aimed to develop a prospective prediction tool on Crimean–Congo haemorrhagic fever (CCHF) to identify geographic regions at risk. The tool could support public health decision makers in implementation of an effective control strategy in a timely manner.

The authors used monthly surveillance data between 2004 and 2015 to predict case counts between 2016 and 2017 prospectively. Turkish nationwide surveillance dataset collected by Ministry of Health contained 10,411 confirmed CCHF cases. We collected potential explanatory covariates about climate, land use, and animal and human population at risk to capture spatiotemporal transmission dynamics. We developed a structured Gaussian process algorithm and prospectively tested this tool predicting the future year’s cases given past years’ cases.. Ak et al. predicted the annual cases in 2016 and 2017 as 438 and 341, whereas the observed cases were 432 and 343, respectively. Pearson’s correlation coefficient and normalized root mean squared error values for 2016 and 2017 predictions were (0.83; 0.58) and (0.87; 0.52), respectively. The most important covariates were found to be the number of settlements with fewer than 25,000 inhabitants, latitude, longitude, and potential evapotranspiration (evaporation and transpiration). Main driving factors of CCHF dynamics were human population at risk in rural areas, geographical dependency, and climate effect on ticks. The model develop by the authors was able to prospectively predict the numbers of CCHF cases. This validation study has also helped to understand the possible mechanisms of infectious diseases and to outline the main orientations for the practice and the policy of fight against emerging infectious diseases.

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Join the COMBACTE GCP Training Balkan

Are you a clinical or laboratory investigator working in Albania, Kosovo, Macedonia or Montenegro? Join our free Good Clinical Practice training on the 26th and 27th of June in Podgorica, Montenegro to refresh and share your knowledge! This face-to-face training consists of plenary sessions, interactive discussions and exercises based on real life trial situations. Not only will you be able to network with our experts, and fellow investigators, you will also be adding to your knowledge of clinical research. This training is offered by COMBACTE (Combatting Antimicrobial Resistance in Europe) in collaboration with EFGCP (European Forum for Good Clinical Practice), and we look forward to introducing you to COMBACTE’s unique clinical research network in Europe.

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Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer

The work of our recipient of the ESCMID 2018 Research Grant: Christian Lesterlin, provides the first example of the key role of a multidrug efflux complex in the acquisition of drug-specific resistance by horizontal gene transfer and was published last week in Science. Drug-resistance dissemination by horizontal gene transfer remains poorly understood at the cellular scale. Using live-cell microscopy, Christian Lesterlin et al. reveal the dynamics of resistance acquisition by transfer of the Escherichia coli fertility factor-conjugation plasmid encoding the tetracycline-efflux pump TetA. The entry of the single-stranded DNA plasmid into the recipient cell is rapidly followed by complementary-strand synthesis, plasmid-gene expression, and production of TetA. In the presence of translation-inhibiting antibiotics, resistance acquisition depends on the AcrAB-TolC multidrug efflux pump, because it reduces tetracycline concentrations in the cell. Protein synthesis can thus persist and TetA expression can be initiated immediately after plasmid acquisition. AcrAB-TolC efflux activity can also preserve resistance acquisition by plasmid transfer in the presence of antibiotics with other modes of action.

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ECCMID 2019 on focus

The highlights of ECCMID 2019 were summarized in Lancet Infect Dis and Infection.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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