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26 February 2019

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,

ESCMID Executive Office.


ESCMID Award for Excellence: Prof. Ron Dagan

The ESCMID Award for Excellence in Clinical Microbiology and Infectious Diseases is our most prestigious award. For 2019, the ESCMID Executive Committee selected Prof. Ron Dagan as recipient of this prestigious award.

Prof. Dagan’s main interest lies in pneumococcal infections and, in particular, in their prevention. His rigorous and exhaustive multifaceted studies on the impact of pneumococcal conjugate vaccines (PCVs) have aimed at a large spectrum of outcomes that, in addition to immunological and clinical outcomes, also include microbiological outcomes (i.e. impact on interaction between pneumococci and other bacteria and viruses; antibiotic resistance).

Prof. Dagan will receive his award at ECCMID 2019 in Amsterdam during the Excellence Award session on Saturday 13 April 2019. During the ceremony, he will give his recipient lecture entitled “PCVs: The first vaccines against normal nasopharyngeal microbiota constituents”.

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Registration for ECCMID 2019

ECCMID is approaching soon in Amsterdam!

Registrations are available at a reduced rate for ESCMID members on the official website.

Make sure you use our official website to book your hotels to get the best rates.

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ESCMID Postgraduate Education Course Announcements

Don’t miss the exciting ESCMID Postgraduate Courses scheduled in 2019!

Recently released for registration are courses in Florence, Genoa, Grenoble and Lausanne.

Visit the courses and workshops page on the ESCMID website to view the current courses.

Reduced membership rates and attendance grants are available for ESCMID members.

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Pre-ECCMID Machine Learning for Microbiology Workshop

Complement your ECCMID 2019 experience with the 'Machine Learning for Clinical Microbiology' the day before ECCMID in Amsterdam.
This workshop is happening on Friday, 12 April. Sign up using the ECCMID registration portal!

Limited places are available, the full day is only €100!

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CMI Highlight: The impact of vaccines on heterologous adaptive immunity

Messina et al. Discussed current evidence of immunomodulation induced by vaccination of adaptive immune cells and heterologous adaptive immune responses.

Vaccines induce antigen-specific memory in adaptive immune cells that enable long-lived protection against the target pathogen.
In addition, several vaccines have beneficial effects superior to protection against their target pathogen.
It is proposed that these nonspecific effects result from immunomodulation induced by a vaccine.
In the case of Bacille Calmette-Guérin (BCG) vaccine, this involves induction of innate immune memory, termed ‘trained immunity’, in monocytes and natural killer (NK) cells.
The three vaccines associated with all-cause infant mortality changes: BCG, diphtheria-tetanus-pertussis (DTP) and measles-containing vaccines (MCV) affect T and B cell immunity.
The majority of studies examining non-specific effects of these vaccines on the adaptive immune system report changes in numbers or proportions of adaptive immune cell populations.
However, there is also evidence of the effects of these vaccines on the function of adaptive immune cells and responses to heterologous stimuli.
There is some evidence that, in addition to BCG, DTP and MCV, other vaccines (which have not been associated with all-cause mortality changes) may alter adaptive immune responses to unrelated stimuli.

This review concludes that vaccines modify adaptive immune cell populations and heterologous immune responses.
The non-specific effects differ between various vaccines and their effects on heterologous adaptive immune responses may also involve bystander activation, cross-reactivity and other as yet undefined mechanisms.
This has major implications for future vaccine design and vaccination schedule.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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