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20 February 2018
WEEKLY NEWS

Dear colleagues,

Please be aware that there are once again several fraudulent websites that imitate our congress website. We recommend that you only use the official website www.eccmid.org for registration and hotel bookings.

Your ESCMID communications editors

 

Check out the scientific programme for ECCMID 2018!

The scientific programme for ECCMID from 21 – 24 April 2018 in Madrid, Spain, is live on the congress website now. You will find the titles of presentations, sessions, content and presenters. Within the preselection you can choose a date to see all scheduled sessions at a glance or browse by session or topic. To get full access, please login with your ESCMID account. As a registered ESCMID user you will be able to create your personal programme for your congress visit and you can also evaluate sessions after they take place to receive CME credits. The abstracts accepted for presentation at ECCMID will become available on 11 April 2018. 

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ESCMID research grantee publishes paper on cytomegalovirus

Fabienne Haspot-Degauque, who received an ESCMID research grant from ESCMID in 2010 published the paper Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene in Plos One this month. Human cytomegalovirus (HCMV) primary infection or reactivation can cause severe pathologies in non-immunocompetent individuals. Fabienne hypothesized that disrupting the UL122/123 gene, a key regulator of lytic replication and reactivation from latency, with the fast and highly potent genome-editing tool CRISPR/Cas9 system based on one or three gRNAs would prevent viral replication. The multiplex strategy excised the immediate early (IE) gene in 90% of all viral genomes and thus led to the inhibition of IE protein expression. Consequently, viral genome replication and late protein expression were reduced by 90%. Finally, the production of new viral particles was nearly abrogated. She concluded that the multiplex anti-UL122/123 CRISPR/Cas9 system can target the viral genome efficiently enough to significantly prevent viral replication.

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CMI highlight: how to determine susceptibility of anaerobic bacteria

In addition to classical time-consuming identification methods and automated biochemical tests, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized identification of even unusual and slow growing anaerobic bacteria directly from culture plates. Researchers from the ESCMID study group for anaerobic infections (ESGAI) reviewed anaerobic diagnostics methods available by routine laboratories. The aims of this review were to discuss the presence of anaerobes in commensal microbiota and in infectious processes, and to present optimal methodology for carrying out anaerobic diagnostics of human infections.

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Course on antimicrobial stewardship in veterinary medicine on 4 April 2018

The ESCMID study groups for veterinary microbiology (ESGVM) and antimicrobial stewardship (ESGAP) will organize a course on the challenges in veterinary hospital infection control in Birmingham, United Kingdom, on 4 April 2018. The course will be hosted by the annual BSAVA congress (5 – 8 April 2018), one of the largest veterinary conferences worldwide. The objectives are to promote hospital infection control and antimicrobial stewardship in small animal practice and to educate a new generation of veterinary infectious disease specialists to be able to develop and implement infection control programmes and antimicrobial stewardship programmes.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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