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20 August 2019

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,
ESCMID Executive Office.


The Second Course on Precision Medicine (Rome, Italy, 26–28 September 2019) has been accredited with nine (9) European CME credits!

The ESCMID Parity Commission is pleased to communicate that the Second Course on Precision Medicine (Rome, Italy, 26 – 28 September 2019) has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with nine (9) European CME credits (ECMEC®s). 

The breakdown of CME credits per day:

26.09.2019 - 2.00

27.09.2019 - 5.00

28.09.2019 - 2.00

Don’t miss this opportunity: click here to register now!

› Read more

Cast your vote in the ESCMID TAE Steering Committee Election 2019!

ESCMID Young Scientist members can now cast their votes in the ESCMID TAE Steering Committee Election 2019 and determine who will represent your interests at our society. Their selection was based on scientific, professional, personal and geographical criteria to ensure a well-balanced ESCMID TAE Steering Committee.

In total there are twelve candidates who have offered their time and energy to represent your interests. So, please select three (3) candidates
at the link below and give them your votes.

The 2019 online election for the TAE Steering Committee is open until Tuesday, 10 September 2019 at 12:00 noon CET.
Only current Young Scientist Members may vote, so make sure you check your membership, and renew if needed. We will announce the results both on the ESCMID website and in a special newsletter in September.

› Read more

Open WHO Antimicrobial Resistance positions

WHO is advertising for two (2) positions in the field of Antimicrobial Resistance.

Descriptions of the positions and requirements can be found at the links below.

Director, Global Coordination and Partnership on AMR

Director, Surveillance, Prevention and Control of AMR

Applications can be submitted at the WHO careers page.

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WHO Biosafety video series - Good Microbiological Practice and Procedures (GMPP)

The WHO have released a seven-part series to its YouTube channel It is hoped that these seven new films will be of help in enhancing safety in any health laboratories, particularly, but not limited to, resource-limited countries.  

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CMI Highlight: Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men

J. Koetsveld et al, set out to study C6 reactivity upon infection with B. miyamotoi in a large well-characterized set of Borrelia miyamotoi disease (BMD) patient sera and in experimental murine infection.

Borrelia miyamotoi is a relapsing fever Borrelia, transmitted by hard (Ixodes) ticks, which are also the main vector for Borrelia burgdorferi. A widely used test for serodiagnosis of Lyme borreliosis is an EIA based on the C6 peptide of the B. burgdorferi sl VlsE protein.

The authors performed in-silico analyses, comparing the C6-peptide to immunodominant B. miyamotoi variable large proteins (Vlps). Next, the authors determined C6 reactivity in sera from mice infected with B. miyamotoi and in a unique longitudinal set of 191 sera from 46 BMD patients.

In-silico analyses revealed similarity of the C6-peptide to domains within B. miyamotoi Vlps. Cross-reactivity against the C6-peptide was confirmed in 21/24 mice experimentally infected with B. miyamotoi. Moreover, 35/46 BMD patients had a C6 EIA Lyme-index higher than 1.1 (positive). Interestingly, 27/37 patients with a C6 EIA Lyme-index higher than 0.9 (equivocal) were negative when tested for specific B. burgdorferi sl antibodies using a commercially available immunoblot.

J. Koetsveld et al, show that infection with B. miyamotoi leads to cross-reactive antibodies to the C6-peptide. Since BMD and Lyme borreliosis are found in the same geographical locations, caution should be used when relying solely on C6-reactivity testing. The authors propose that a positive C6 EIA with negative immunoblot, especially in patients with fever several weeks after a tick bite, warrants further testing for B. miyamotoi.

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Organization and training at national level of antimicrobial stewardship and infection control activities in Europe: an ESCMID cross-sectional survey

Antimicrobial stewardship (AMS) and Infection prevention and control (IPC) are two key complementary strategies that combat development and spread of antimicrobial resistance. The ESGAP (ESCMID Study Group for AMS), EUCIC (European Committee on Infection Control) and TAE (Trainee Association of ESCMID) investigated how AMS and IPC activities and training are organized, if present, at national level in Europe.

From February 2018 to May 2018 an internet-based cross-sectional survey was conducted through a 36-item questionnaire involving up to three selected respondents per country, from 38 European countries in total (including Israel) belonging to the ESGAP/EUCIC/TAE networks. All 38 countries participated with at least one respondent and a total of 81 respondents. Education and involvement in AMS programmes were mandatory during the postgraduate training of clinical microbiology and infectious diseases specialists in up to one-third of countries. IPC was acknowledged as a specialty in 32% of countries. Only 32% of countries had both guidance and national requirements regarding AMS programmes, in contrast to 61% for IPC. Formal national staffing standards for AMS and IPC hospital-based activities were present in 24% and 63% of countries respectively.

The backgrounds of professionals responsible for AMS and IPC programmes varied tremendously between countries. The organization and training of AMS and IPC in Europe are heterogeneous and national requirements for activities are frequently lacking.

› Read more
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