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9 October 2018

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,

ESCMID Executive Office.


ESCMID and IDSA meeting at IDWeek in San Francisco

ESCMID and IDSA executive representatives met during IDWeek in San Francisco, USA. Both societies will continue their collaboration in different aspects, including guidelines development.

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Open Calls | Applications

ECCMID Abstract submission is open!

Submission of abstracts for ECCMID 2019 is open, and will close on 28 November 2018.

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EMA press release on quinolone use

Following a review of disabling and potentially long-lasting side effects reported with quinolone and fluoroquinolone medicines EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) has recommended restricting the use of these medicines.
Very rarely, patients treated with fluoroquinolone or quinolone antibiotics have suffered long-lasting and disabling side effects, mainly involving muscles, tendons and bones and the nervous system. The full press release is available here.

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EITaF news: Autochthonous transmission of Dengue in Spain, Monkeypox update

Spanish health authorities have notified the first cases of dengue in
Spain with autochthonous transmission. On October 4, 2018 the National Center of Microbiology of the Health Institute Carlos III confirmed two cases of Dengue virus infection in two adults living in Spain. None of them had traveled outside Spain in areas with known transmission of Dengue virus before the onset of symptoms.

2 new cases of Monkeypox, arriving from Nigeria, have also been noted in the United Kingdom, as well as 1 case in Israel.

Read more on the EITaF web page.

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CMI highlight: Impact of Antimicrobial Treatment Duration on Outcome of Staphylococcus aureus Bacteremia

Kim et al compared the outcome of Staphylococcus aureus bacteremia (SAB) in light of treatment duration in 2098 patients with or without complicating factors (such as persistent bacteremia, metastatic infection, prosthesis and endocarditis) that may necessitate longer antibiotic treatment. Of the 1866 patients in whom the outcome was analyzed, 591 showed poor outcomes. On multivariate analysis, age over 65 years, pneumonia, higher SOFA score and chronic liver diseases were risk factors for poor outcome. Administration of antibiotics less than the recommendation was associated with poor outcome, but this significance was observed only in the longer antibiotic treatment warranted (LW) group (adjusted odds ratio 1.68, 95% confidence interval 1.00-2.83, p=0.05). Together these data indicate that inappropriate short antibiotic treatment was associated with poor outcome in the LW-group. The authors suggest vigilant evaluation for risk factors to determine the duration of treatment in order to improve the outcome among patients with SAB.

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NEJM publication for previous Young Investigator Award winner

2017 ESCMID Young Investigator Award winner David Eyre and colleagues have recently had his paper ‘Controlling a Candida auris outbreak’ published in the New England Journal of Medicine.

David Eyre summarized their study for the ESCMID Newsletter:

A total of 70 patients were colonised or infected with Candida auris in an outbreak centred around the hospital’s neuroscience intensive care unit. An intensive patient and environmental screening program was instituted. C. auris was rarely isolated in the general environment, but was recovered from reusable monitoring equipment, in particular from multiple skin surface temperature probes used for continuous patient monitoring. A case-control study identified use of these temperature probes as a strong risk factor for colonisation/infection after controlling for length of stay and patient vital signs and laboratory results (odds ratio 6.8). Despite a bundle of infection-control interventions, the incidence of new cases was reduced only after removal of the temperature probes. Whole genome sequencing was used to demonstrate that all patient and environmental samples arose from a single introduction into Oxford of the South African C. auris clade. Sequenced isolates from environmental samples were highly related to those from patients. These findings together strongly implicate reusable skin surface temperature probes as an important source of C. auris transmission during the outbreak. This study highlights how this emerging pathogen can persist in the environment and be transmitted in health care settings.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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