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15 October 2019

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,
ESCMID Executive Office.


ECCMID 2020 is approaching: don’t miss the opportunity to enjoy Prof. Anuradha Chowdhary’s Keynote Lecture. Register now!

We are extremely pleased to have Prof. Anuradha Chowdhary, the head of the Department of Medical Mycology at Vallabhbhai Patel Chest Institute (University of Delhi, India), as a keynote speaker at ECCMID 2020!  The title of her lecture will be “Antifungal resistance in the spotlight: Candida auris as an emerging threat”.

Visit the ECCMID 2020 website to find out about our outstanding keynote speakers and to take advantage of early registration discounts!

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ESCMID 2020 Courses now online and available for registration

Registrations are now open for several 2020 ESCMID Postgraduate Education Courses.

Head to the Courses website to view the course programmes and to enroll in the following courses:

- Technical hospital hygiene – Tricks of the trade (Vienna, Austria)

- Antimicrobial Stewardship: a hands-on course and workshop (Paris, France)

- Translation of recent advances in diagnostic methods to clinical microbiology and infectious diseases (Lund, Sweden)

- Postgraduate Course in Clinical Parasitology (Amsterdam, Netherlands)

- Rare Yeasts – A Growing Threat (Iasi, Romania)

- Invasive fungal infections in critically ill patients (Cologne, Germany)

Further courses will be opened for registration soon, and announced in the ESCMID newsletter and social media channels.

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Memorandum of understanding between ESCMID and ESPID

The ESCMID Executive Committed has recently established a Memorandum of Understanding with the European Society for Paediatric Infectious Diseases (ESPID). This formal agreement aims at consolidating the collaboration between the two societies in the field of infectious diseases. In particular, ESCMID and ESPID will create opportunities to co-sponsor educational sessions or workshops at international meetings, co-organise joint sessions at ECCMID and ESPID Annual meeting, co-develop continuing educational activities and websymposiums, co-publish guidelines for the diagnosis and management of infectious diseases in children. 

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IMMEM Presentations are now online!

Missing #IMMEMXII or didn't get a chance to attend?

You can view the presentations online on the ESCMID E-Library at the link below.

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ESICM / ESCMID / IATDMCT / ISAC Position paper: Antimicrobial Therapeutic Drug Monitoring in Critically Ill Adult Patients open for public consultation

The draft version of the "Position paper: Antimicrobial Therapeutic Drug Monitoring in Critically Ill Adult Patients" has now entered into the public consultation phase.
The position paper is a result of the concerted efforts of experts across Europe, from the Working Groups of European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and International Society of Antimicrobial Chemotherapy (ISAC)

The public consultation phase has the aim to give to all ESCMID members the opportunity to participate to the endorsement process, thus ensuring that ESCMID is accurately represented.

The ESCMID members wishing to comment on the manuscript need to express their commitment following this link, They will receive the (confidential) draft of the manuscript along with the comments form for listing feedback.

The deadline for providing feedbacks and comments on the confidential manuscript is 29th of October 2019. If you have any questions, please address them to guidancedocuments@escmid.org

For more information visit our website following this link:

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CMI highlight: Validity of surrogate endpoints assessing central venous catheter-related infection: evidence from individual- and study-level analyses

H-J. de Grooth et al, determine the validity of different endpoints for central venous catheter infections.

The prevention of catheter-related bloodstream infection (CRBSI) has been an area of intense research, but the heterogeneity of endpoints used to define catheter infection makes the interpretation of randomized controlled trials (RCTs) problematic.

The authors source of information came from: 1) Individual-catheter data from 9428 catheters from four large RCTs. 2) Study-level data from 70 RCTs identified with a systematic search. For each RCT the prevalence rates of CRBSI, quantitative catheter tip colonization, catheter-associated infection (CAI) and central line-associated bloodstream infection (CLABSI) were extracted for each randomized study arm.

The criteria for this study was RCTs published between January 1987 and October 2018 investigating short-term central venous catheters or short-term dialysis catheters performed on adult patients requiring short-term central venous access during various interventions to reduce catheter infections.

CRBSI was used as the gold-standard endpoint, for which colonization, CAI and CLABSI were evaluated as surrogate endpoints. Surrogate validity was assessed as: 1) the individual partial coefficient of determination (individual-pR2) using individual-catheter data; 2) the coefficient of determination (study-R2) from mixed-effect models regressing the therapeutic effect size of the surrogates on the effect size of CRBSI, using study-level data.

The authors concluded that CAI is a moderate to good surrogate endpoint for CRBSI. Colonization and CLABSI should be interpreted with caution they do not reliably reflect treatment effects on CRBSI.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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