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11 May 2021
WEEKLY NEWS

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,
ESCMID Executive Office.

 

Pre-ECCMID Days – Catch the sessions on-demand!

Did you know that all of the sessions from the pre-ECCMID days are available to watch on-demand after the live presentations?

Log into the ECCMID Online Platform, and choose ‘On-Demand’ from the menu to access the sessions from the previous pre-ECCMID days.

› Read more

ESCMID Professional Affairs Webinar: Clinical microbiologists and infectious diseases specialists during the turmoil of the COVID-19 pandemic

The ESCMID Profession Affairs Webinar will take place tomorrow, 12 May 2021, 16:00 – 18:00 CEST. This webinar is free of charge and limited places are still available, so register now!

For more than one year now, clinical microbiologists (CM) and Infectious Diseases (ID) specialists have been involved in one of the greatest pandemics of the beginning of the century.

Many colleagues were overwhelmed by patients with COVID-19 and others were exhausted by testing patients and asymptomatic persons for SARS-CoV-2.

In this webinar, we will focus for the first time on the professionals themselves, and not on the disease nor the microorganism, shifting focus instead onto the colleagues living this turmoil.

You will find more information such as the programme as well as the link to register for free at the link below.

› Read more

ESCMID Study Group Research Grants 2021: Call opening and closing dates.

In 2021, ESCMID will support Study Group research projects in the fields of clinical microbiology and infectious diseases. The call to apply for the ESCMID Study Group Research Grants will officially open 17 May 2021 and the deadline for submitting your applications is 23 July 2021, 17:00 CEST.

All the information regarding the ESCMID Study Group Research funding are available here.

Please carefully read the updated “What you need to apply” section: important changes have been made compared to the previous call.

› Read more
 

ECCMID Slam Poetry Workshops - sign up today!

For ECCMID 2021, we are happy to be hosting 4 slam poetry workshops, one on each day of ECCMID, where participants can meet up in the company of a slam poet to express their life experiences during the COVID-19 Pandemic through the medium of slam poetry.

Slam poetry is an exciting artform that brings the classic expressiveness of poetry into a less-structured and more accessible package!

It could be about what has been happening in your hospital, at home or even online – whatever it is, we want to hear you slam about it!

A valid ECCMID registration is required in order to register for the workshop.

› Read more
 

Online Education Course announcement

The ESCMID Online Postgraduate Education Course ‘Next-generation Sequencing in routine clinical microbiology and infectious diseases’ is now open for registration!

Check out the programme flyer for all of the details, and visit the ESCMID online courses website to sign up for this and other great ESCMID online courses.

› Read more
 

CMI highlight: Lysosomal alkalization to potentiate eradication of intraosteoblastic Staphylococcus aureus in the bone and joint infection setting

Beyond intracellular penetration, acidic lysosomal pH might affect the intracellular activity of some antimicrobials. This study evaluated the ability of lysosomotropic alkalizing agents to potentiate antimicrobial eradication of intraosteoblastic S. aureus reservoir in the bone and joint infection (BJI) setting. MICs of sixteen anti-staphylococcal molecules against MSSA were evaluated at pH 5 and 7. Additionally, lysosomal alkalinizing potential (spectrofluorometry) and cytotoxicity (MTT assay) of hydroxychloroquine, amantadine and NH4Cl were assessed.

Results led to further investigate clindamycin, cotrimoxazole, daptomycin and levofloxacin in an in vitro model of osteoblast infection, alone or in combination with hydroxychloroquine. The impact of hydroxychloroquine on autophagy was finally investigated, using Western blot detection of two autophagic flux indicators, the LC3 membrane protein and the SQSTM1 cargo protein. It emerged that at high concentrations, hydroxychloroquine used as an adjuvant to antimicrobials improves eradication of S. aureus intraosteoblastic reservoir in our in vitro cell infection model. Authors further conclude that these findings advocate for further in vivo evaluation of alkalization efficacy and tolerance in S. aureus BJI.

› Read more
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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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