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11 June 2019
WEEKLY NEWS

Dear colleagues,

Please find below the latest edition of ESCMID Weekly News.

With kind regards,

ESCMID Executive Office.

 

First ECCMID 2020 Programme Committee Meeting, Palma

The first Programme Committee for ECCMID 2020 took place last week in Palma de Mallorca, Spain.

This meeting is the first of two that brings together experts in the fields of Clinical Microbiology and Infectious Disease to build the invited and abstract programme of ECCMID 2020 in Paris.

ASM/ESCMID Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance – Boston, United States

Don’t miss out on our annual collaborative event with ASM, the Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance.

Abstract submission is open until July 8 2019!

Find out more on the conference website.

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Trainee Association of ESCMID - Trainee Survey

Research has been recognised as one of the key competencies in post-graduate medical education. However, conducting research during clinical training is a challenge for many. This survey aims to assess research competencies of CM & ID trainees and identify factors associated with involvement in research during specialist clinical training (residency) with an ultimate aim of identifying the gaps and disparities in the training, therefore, to inform curriculum development in CM & ID training.

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5th ESCMID Conference on Vaccines – Abstract submissions closing soon

Abstract submission for the 5th ESCMID Conference on Vaccines, to be held in Bilbao, Spain in September this year, closes on 15 June 2019 at 23:59 CEST.

Don’t miss out on the chance to share your research findings with colleagues from across Europe and the world. Find out more about the Conference and the abstract submission guidelines on the conference website.

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EITaF Postgraduate Course in Florence, May 2019

The ESCMID Emerging Infections Task Force, EITaF, conducted a workshop the 13th to the 15th May: Emerging infections for clinicians and the WHO Emerging Diseases Clinical Assessment and Response Network (EDCARN) in collaboration with the University of Florence, Professor Alessandro Bartoloni, and the WHO, Dr Janet Diaz, the Erasmus Medical Center, Rotterdam, Professor Marion Koopmans and the Foundation For Innovative New Diagnostics FIND, Dr Sabine Dittrich. The aim of the workshop was to bridge the gap between new advanced diagnostics methods, surveillance and clinical infectious disease. Syndromatic surveillance was discussed and new diagnostics methods such as whole genome sequencing, metagenomics, and advanced methods in serology were reviewed. The European laboratory networks co-ordinated by the European CDC, ECDC, were presented.The last day of the course was a presentation of the WHO Emerging Diseases Clinical Assessment and Response Network (EDCARN) with on-line presentations from the WHO in Geneva and the WHO Ebola response team (Dr Diaz) present on-line from the Democratic Republic of the Congo, DRC. The current status of the attempt to control the Ebola outbreak in the DRC was presented and discussed. The workshop received an evaluation score of 3.5 out of 4, and the EITaF team encourage interested ESCMID members to sign up for the EITaF news on the ESCMID website.

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CMI Highlight: Association of a single nucleotide polymorphism in ubxn6 gene with long term non progression phenotype in HIV-positive individuals

F. Díez-Fuertes et al. aim in the present study to identify host single nucleotide polymorphisms (SNPs) associated with non-progression in a cohort of 352 individuals members of a long-term non-progressors (LTNP) heterogeneous group of HIV-positive individuals. This group is characterized by their ability to maintain high CD4+ T-cell counts and partially control viral replication for years in the absence of antiretroviral therapy. DNA microarrays and exome sequencing were used for genotyping about 240,000 functional polymorphisms throughout more than 20,000 human genes. The allele frequencies of 85 LTNPs were compared with a control population. SNPs associated with LTNPs were confirmed in a population of typical progressors. Functional analyses in the affected gene were carried out through knockdown experiments in HeLa-P4, macrophages and dendritic cells.Several SNPs located within the MHC region previously related to LTNPs were confirmed in this new cohort. The SNP rs1127888 (UBXN6) surpassed the statistical significance of these markers after Bonferroni correction (q=2.11x10-6). An uncommon allelic frequency of rs1127888 among LTNPs was confirmed by comparison with typical progressors and other publicly available populations. UBXN6-knockdown experiments caused an increase of CAV1 expression and its accumulation in the plasma membrane of different cell types. In vitro infection of these cells with HIV-1 replication-competent recombinant viruses caused a reduction of the viral replication capacity compared with their corresponding wild type cells expressing UBXN6.
The authors conclude that a higher prevalence of Ala31Thr in UBXN6 was found among LTNPs within its N-terminal region, which is crucial for UBXN6/VCP protein complex formation. UBXN6-knockdown affected CAV1 turnover and HIV-1 replication capacity.

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The ESCMID Newsletter is issued on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) by the ESCMID Executive Office. It contains announcements of ESCMID-related matters and other information of interest to professionals in the infection field.

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