Presentations & Publications

A mini-review and consensus statement by EPASG in collaboration with ISAP concerning in vitro pharmacodynamic testing of protein binding of antibiotics has been accepted by Antimicrobial Agents and Chemotherapy. An online version will be available soon.

EPASG additionally published a book chapter on protein binding: 
Antimicrobial Distribution and Drug-Drug Interaction in Cancer Patients. Ursula Theuretzbacher, Markus Zeitlinger. In: Principles and Practice of Cancer Infectious Diseases. Safdar, Amar (Ed.), 1st Edition, 2011, 549 p. 122 illus., 74 in color. Humana Press, Hardcover, ISBN 978-1-60761-643-6, Series: Current Clinical Oncology.

Project leader:  Ursula Theuretzbacher

Conserving antibiotics for the future - New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective

Johan W. Mouton, Paul Ambrose, Rafael Canton, George L. Drusano, Stephan Harbarth, Alasdair MacGowan, Ursula Theuretzbacher and John Turnidge

Drug Resist Updat. 2011 Mar 25. [Epub ahead of print]

As a result of the Uppsala Conference “Global Need for Effective Antibiotics-Moving towards Concerted Action” (see news item below) members of EPASG submitted this publication to the journal “Drug Resistance Updates” in collaboration with ISAP.

This invitational conference recommended concrete solutions to critical issues such as establishing a framework for priority setting for research and development of new drugs and diagnostic methods, enhancing knowledge-sharing for drug discovery, and explore different combinations of incentives to reinvigorate the innovation of new antibacterials. The foremost target groups for the conference were the EU Commission, the EU-US Task force on Antimicrobial Resistance and the WHO.
The Core group “New Ways of Using Old and Coming Antibiotics - Development of Combination Therapies, Dosage and Cycling” was chaired by Johan Mouton and several EPASG members were also involved.
In a meeting in Cologne we produced background documents which served as the basis for the workshop discussions and the later publication of the proceedings of the conference. A publication has been submitted with action recommendations.

Project Leader: Otto Cars